Keratoacanthoma and squamous cell carcinoma are distinct from a molecular perspective

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Seong H RaScott Binder


Keratoacanthoma is a controversial entity. Some consider keratoacanthoma as a variant of squamous cell carcinoma, whereas others see it as a distinct self-resolving squamoproliferative lesion. Our objective is to examine the relationship of keratoacanthoma with squamous cell carcinoma and normal skin by using DNA microarrays. DNA microarray studies were performed on formalin-fixed and paraffin-embedded blocks from ten cases of actinic keratoacanthoma utilizing the U133plus2.0 array. These results were compared with our previously developed microarray database of ten squamous cell carcinoma and ten normal skin samples. Keratoacanthoma demonstrated 1449 differentially expressed genes in comparison with squamous cell carcinoma (>5-fold change: P<0.01) with 908 genes upregulated and 541 genes downregulated. Keratoacanthoma showed 2435 differentially expressed genes in comparison with normal skin (>5-fold change: P<0.01) with 1085 genes upregulated and 1350 genes downregulated. The most upregulated genes, comparing keratoacanthoma with normal skin included MALAT1, S100A8, CDR1, TPM4, and CALM1. The most downregulated genes included SCGB2A2, DCD, THRSP, ADIPOQ, adiponectin, and ADH1B. The molecular biological pathway analysis compari...Continue Reading


Dec 1, 1994·Journal of Cutaneous Pathology·J P SleaterJ B Hendricks
Aug 1, 1993·The American Journal of Dermatopathology·E HodakA B Ackerman
Aug 8, 2001·The Australasian Journal of Dermatology·A M GodboltDavid Weedon
Apr 13, 2004·Journal of Leukocyte Biology·Saeid GhavamiFatemeh Karami-Tehrani
Jun 3, 2005·Clinical Medicine & Research·Ilene B Bayer-GarnerJaime A Tschen
May 27, 2006·The Journal of Investigative Dermatology·Ole Petter F ClausenPaula M DeAngelis
Jun 20, 2006·Pathology, Research and Practice·Tanja BatinacGordana Zauhar
Dec 19, 2006·Cancer Biology & Therapy·Jin HeJia Le Dai
Jul 27, 2007·Journal of Cellular Biochemistry·Yabing ChenJay M McDonald
Jan 24, 2009·International Journal of Cancer. Journal International Du Cancer·Natasa VasiljevićOla Forslund
Dec 4, 2009·Pathology Oncology Research : POR·Fengjin QinLi Geng
Jan 2, 2010·Seminars in Diagnostic Pathology·Joshua C Mandrell, Daniel Santa Cruz
Jun 26, 2010·ANZ Journal of Surgery·David WeedonRichard Williamson
Jul 12, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Seong Hui RaScott Binder
Nov 18, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lars Henning SchmidtCarsten Muller-Tidow
Sep 28, 2012·The Journal of Investigative Dermatology·Rajan P KulkarniScott Binder
Feb 2, 2013·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Seong H RaScott Binder
Dec 25, 2013·The American Journal of Dermatopathology·Jacqueline A Savage, John C Maize


Mar 4, 2017·The Journal of Dermatology·Toshihiro Takai
Mar 24, 2017·The Journal of Dermatology·Noriyuki MisagoTomokazu Nakao
Aug 2, 2017·The British Journal of Dermatology·R E WatchornS M Taibjee
Aug 6, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·J P Bandino, D M Elston
Nov 11, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·D SartiniM Emanuelli
Jul 12, 2019·Scientific Reports·Shreshtha MalviaSunita Saxena
Jun 22, 2018·Oncology Letters·Miaomiao ZhaoXiaowei Liu
Jul 21, 2020·International Journal of Dermatology·Gabrielle BrodyKenneth Linden
Oct 18, 2015·Experimental Dermatology·Tobias GleichDaniel Hohl
May 18, 2018·Frontiers in Microbiology·Daniel HascheFrank Rösl
Apr 13, 2019·Head and Neck Pathology·Efthimios SivridisAlexandra Giatromanolaki
Jan 5, 2021·The American Journal of Dermatopathology·Alexander NirenbergAnthony Dixon

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Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Seong Hui RaScott Binder
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