Keratoacanthoma and squamous cell carcinoma are distinct from a molecular perspective

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Seong H RaScott Binder

Abstract

Keratoacanthoma is a controversial entity. Some consider keratoacanthoma as a variant of squamous cell carcinoma, whereas others see it as a distinct self-resolving squamoproliferative lesion. Our objective is to examine the relationship of keratoacanthoma with squamous cell carcinoma and normal skin by using DNA microarrays. DNA microarray studies were performed on formalin-fixed and paraffin-embedded blocks from ten cases of actinic keratoacanthoma utilizing the U133plus2.0 array. These results were compared with our previously developed microarray database of ten squamous cell carcinoma and ten normal skin samples. Keratoacanthoma demonstrated 1449 differentially expressed genes in comparison with squamous cell carcinoma (>5-fold change: P<0.01) with 908 genes upregulated and 541 genes downregulated. Keratoacanthoma showed 2435 differentially expressed genes in comparison with normal skin (>5-fold change: P<0.01) with 1085 genes upregulated and 1350 genes downregulated. The most upregulated genes, comparing keratoacanthoma with normal skin included MALAT1, S100A8, CDR1, TPM4, and CALM1. The most downregulated genes included SCGB2A2, DCD, THRSP, ADIPOQ, adiponectin, and ADH1B. The molecular biological pathway analysis compari...Continue Reading

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Citations

Mar 4, 2017·The Journal of Dermatology·Toshihiro Takai
Mar 24, 2017·The Journal of Dermatology·Noriyuki MisagoTomokazu Nakao
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Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Seong Hui RaScott Binder
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