Keratoacanthoma clinical behavior: a systematic review

The American Journal of Dermatopathology
Jacqueline A Savage, John C Maize

Abstract

As of 2013, keratoacanthomas (KAs) have not been decided on as either a benign or a malignant entity. Originally considered benign epidermal growths, the assertion by Hodak, Jones, and Ackerman that these lesions are truly "an expression of squamous cell carcinoma" (SCC) fueled the controversy and placed some of the biggest names in the field on opposite sides of the issue. Without a clear understanding of the etiology of KAs and without stringent diagnostic criteria, the literature in regard to KA contains scant reports of their "metastatic potential." Four hundred forty-five cases of KA with reported follow-up and outcomes were reviewed from 113 published articles. In our data set, none of these cases resulted in death or distant metastases. When compared with 429 cases of SCC of the skin, with 61 cases of metastases and 24 deaths as a direct result of SCC, the biologic behavior of the 2 entities is distinct and evident. KAs are benign epidermal growths and not a malignant variant of SCC.

References

Jan 1, 1979·The British Journal of Dermatology·A Rook, I Whimster
Dec 1, 1978·Archives of Dermatology·R B Odom, D K Goette
Jan 1, 1977·Archives of Dermatology·C Dei RossiD Simonetto
Feb 1, 1977·The British Journal of Venereal Diseases·K Lejman, Z Starzycki
Jul 1, 1976·Archives of Dermatology·W L Macaulay
Oct 1, 1992·The American Journal of Dermatopathology·E Calonje, E W Jones
Jan 1, 1986·Ophthalmic Plastic and Reconstructive Surgery·D J BerginT A Deffer
Sep 1, 1988·Archives of Dermatology·P H Cooper, J T Wolfe
Feb 1, 1985·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·F E Lucente
Mar 1, 1986·The Journal of Dermatologic Surgery and Oncology·W A PaganiD Lorusso
May 1, 1985·Gynecologic Oncology·R M Rhatigan, R C Nuss
Apr 1, 1966·The Journal of Pathology and Bacteriology·A J Webb, F N Ghadially
Jan 1, 1967·Archives of Dermatology·G B Elliott, B K Fisher
Oct 1, 1983·The British Journal of Dermatology·S Sayama, H Tagami
Nov 1, 1983·Archives of Dermatology·D K Goette
Apr 1, 1984·The American Journal of Dermatopathology·F PiscioliM Cristofolini
Sep 1, 1981·Journal of the American Podiatry Association·H W Ritchlin, R J Gensheimer
Nov 1, 1981·The Journal of Dermatologic Surgery and Oncology·S WolinskyE W Herman
Jun 1, 1995·British Journal of Plastic Surgery·L N Hurst, B S Gan
Aug 1, 1993·The American Journal of Dermatopathology·E HodakA B Ackerman
Aug 1, 1996·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·A JanetteM W Lingen
May 1, 1997·Obstetrics and Gynecology·S GilbeyG P Sutton
Jun 1, 1997·Acta Ophthalmologica Scandinavica·S A SchelliniC E Bacchi
Oct 6, 1997·Journal of the American Academy of Dermatology·M W DessoukeyH Abdel-Dayem
Jan 7, 1998·Journal of the American Academy of Dermatology·C de la TorreM J Cruces
May 15, 1998·Archives of Dermatology·C Cuesta-Romero, J de Grado-Peña
Aug 26, 1998·The British Journal of Ophthalmology·S E CouplandW R Lee
Nov 17, 1998·Fortschritte der Medizin·T JansenG Plewig
Aug 18, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·M AgarwalR Walia
Dec 3, 1999·The British Journal of Dermatology·S Radakovic-FijanA Tanew
Mar 25, 2000·Auris, Nasus, Larynx·M MoriyamaG Mogi
Jul 15, 2000·Dermatology : International Journal for Clinical and Investigative Dermatology·K SpiethR Kaufmann
Aug 8, 2001·The Australasian Journal of Dermatology·A M GodboltDavid Weedon
Jan 5, 2002·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Jan G A M de VisscherFeike Willemse
Mar 19, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Basil S CherpelisPearon G Lang
Nov 2, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Scott SandersKishwer S Nehal
Nov 22, 2002·Dermatology : International Journal for Clinical and Investigative Dermatology·Robert A SchwartzStefania Jablonska
Dec 21, 2002·International Journal of Dermatology·Kabir SardanaSeema Sethi
Jan 14, 2003·Archives of Ophthalmology·Kaori KifukuTatsuro Ishibashi
Feb 13, 2003·Journal of the American Academy of Dermatology·Sean F Pattee, Nancy G Silvis
Feb 13, 2003·Journal of the American Academy of Dermatology·Yumie OgasawaraMasahiko Muto
Jul 18, 2003·Ophthalmology·Mark J DonaldsonRichard M Williamson
Aug 21, 2003·Eye·E H HughesD M Tole
Jun 5, 1954·Journal of the American Medical Association·E J LEVYH BEERMAN
May 18, 1957·Lancet·C H WHITTLE, R A DAVIS
Jul 1, 1962·Archives of Dermatology·I SILBERBERGR L BAER
Sep 27, 2003·Journal of the American Academy of Dermatology·N KatoM Shibata
Nov 18, 2003·The Australasian Journal of Dermatology·Leah M GieseckeS C Huilgol
Apr 21, 2004·Journal of the American Academy of Dermatology·Leonard H GoldbergMurad Alam
Apr 22, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Cristina MangasCarlos Ferrándiz
Jun 24, 2004·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Wen Chen, Christopher Koenig
Aug 3, 2004·Revista do Hospital das Clínicas·Fernanda Braga PerdigãoMaria Letícia Cintra
Aug 17, 2004·British Journal of Plastic Surgery·Richard W Griffiths
Aug 25, 2004·Journal of the European Academy of Dermatology and Venereology : JEADV·V Di LerniaG Albertini
Dec 4, 2004·Journal of the American Academy of Dermatology·Chang-Keun OhKyung-Sool Kwon
Dec 21, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jens J ThielePeter Elsner
Apr 22, 2005·The Australasian Journal of Dermatology·Amanda Oakley, Stephen Ng
May 3, 2005·Gynecologic Oncology·Marcelo Carraro NascimentoAndreas Obermair
Aug 23, 2005·The British Journal of Ophthalmology·I LeibovitchD Selva
Jan 6, 2006·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Betty A Hinderks DavisLanning Kline
Jan 31, 2006·Journal of the European Academy of Dermatology and Venereology : JEADV·A F Kaptanoglu, L Kutluay
Apr 25, 2006·Journal of the American Academy of Dermatology·Sayuri YugeCleverson Teixeira Soares
May 10, 2006·ANZ Journal of Surgery·Dinesh RatnapalaHelen Mahoney
Jun 15, 2006·Plastic and Reconstructive Surgery·Keith Denkler, William F Kivett
Jun 22, 2006·Annals of Surgical Oncology·John T MullenJanice N Cormier
Aug 16, 2006·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ferda OzkanSuna Cesur
Sep 7, 2006·Acta Dermato-venereologica·Adam ReichJacek C Szepietowski
Jan 3, 2007·Journal of the American Geriatrics Society·Inna Sheyner, Vladimir Osipov
Jan 3, 2007·Journal of the American Geriatrics Society·George I Varughese, Abd A Tahrani
Jan 17, 2007·Journal of the American Academy of Dermatology·Hideyuki UjiieYuki Tomita
May 17, 2007·Journal of the American Academy of Dermatology·Nicole M AnnestDuane C Whitaker
Jun 5, 2007·Pediatric Dermatology·Eliana Maria MinicucciDaniel Araki Ribeiro
Jul 31, 2007·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Aránzazu VergaraAurora Guerra
Nov 21, 2007·Archives of Dermatology·Joe A ChornyJoel L Cohen
Dec 14, 2007·Clinical and Experimental Dermatology·M T V'lckova-Laskoska, D S Laskoski
Jan 5, 2008·International Journal of Dermatology·Kiriaki AroniEfstratios Patsouris
Mar 25, 2008·The American Journal of Dermatopathology·Steven KossardCarolyn Choy
May 20, 2008·Oral Oncology·K Busuttil NaudiK D Hunter
May 24, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·C S SouzaV S Bagnato
Jul 17, 2008·Journal of Cutaneous Medicine and Surgery·Renata Ferreira MagalhãesAparecida Machado de Moraes
Jan 6, 2009·Journal of the American Academy of Dermatology·Amanda Marcollo PiniGünther F L Hofbauer
May 26, 2009·Journal of Applied Oral Science : Revista FOB·Lara Maria A RamosAntônio Francisco Durighetto-Júnior
Jul 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean Philippe ArnaultCaroline Robert
Aug 8, 2009·The Australasian Journal of Dermatology·Anil KurienSimon Lee
Nov 6, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Kathryn DeAmbrosis, Brian De'Ambrosis
Jan 2, 2010·Seminars in Diagnostic Pathology·Joshua C Mandrell, Daniel Santa Cruz
Feb 5, 2010·Pakistan Journal of Biological Sciences : PJBS·N YazdaniA Kouhi
Apr 24, 2010·The American Journal of Dermatopathology·David WeedonRichard Williamson
Jun 26, 2010·ANZ Journal of Surgery·David WeedonRichard Williamson
Jul 24, 2010·The Journal of Dermatology·Je Ho YeonChang Hun Huh
Jul 27, 2010·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Matthew PetrieCarmen Campanelli
Aug 20, 2010·The Journal of Hand Surgery, European Volume·T Underhill
Nov 9, 2010·Clinical and Experimental Dermatology·B ArunD A Fitzgerald
Nov 9, 2010·Clinical and Experimental Dermatology·K D Davies, J H Davies
Nov 27, 2010·Acta Oncologica·Yevgeniy BalagulaPatricia L Myskowski
Feb 22, 2011·The Australasian Journal of Dermatology·Glen Foxton, Tom Delaney
Apr 16, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Gregory T ChesnutGeorge W Turiansky
May 14, 2011·Clinical and Experimental Dermatology·F BrowneG Stables
Sep 23, 2011·The American Journal of Dermatopathology·Noriyuki MisagoYutaka Narisawa
Oct 4, 2011·Indian Journal of Dermatology·Atul ChauhanB Aadithya
Feb 9, 2012·The Australasian Journal of Dermatology·Roberto CecchiStefania Innocenti
Mar 1, 2012·Clinical and Experimental Dermatology·M ShahC Kwok
Mar 17, 2012·Indian Journal of Dermatology, Venereology and Leprology·Maria M FariasSergio Gonzalez
Apr 24, 2012·Journal of the American Academy of Dermatology·Christine J KoKeith A Choate
Jun 21, 2012·Journal of Cutaneous Medicine and Surgery·Nicolas AubutJoël Claveau
Sep 28, 2012·The Journal of Investigative Dermatology·Rajan P KulkarniScott W Binder
Nov 6, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Brooke MohrJennifer Krejci-Manwaring

Citations

Jun 6, 2014·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·L Hübinger, J Frank
May 29, 2015·Cancer Biology & Therapy·Paul R MasseyTito Fojo
Feb 14, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Seong H RaScott W Binder
Dec 28, 2016·Plastic and Reconstructive Surgery·Karen L ConnollyJoseph J Disa
Aug 2, 2017·The British Journal of Dermatology·R E WatchornS M Taibjee
Jun 15, 2018·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Ketty PerisItalian Group of Dermato-Oncology (GIDO) of SIDeMaST
Jan 2, 2020·Journal of Cutaneous Pathology·Priyadharsini Nagarajan
Sep 16, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·R Salido-VallejoJ C Moreno-Giménez
Sep 25, 2015·Medicine·Caroline Siviero DillenburgCristiane Helena Squarize
Jul 9, 2016·Diagnostic Pathology·Jan BeckervordersandforthAxel Zur Hausen
May 15, 2017·Cancer Immunology, Immunotherapy : CII·Thilo GambichlerLutz Schmitz
Sep 28, 2015·Journal of the European Academy of Dermatology and Venereology : JEADV·C BaykalA Polat Ekinci
May 18, 2018·Frontiers in Microbiology·Daniel HascheFrank Rösl
Apr 13, 2019·Head and Neck Pathology·Efthimios SivridisAlexandra Giatromanolaki
Apr 12, 2021·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Hatem KremaFiliberto Altomare

Related Concepts

Keratoacanthoma
Dermatologic Disorders
Squamous Cell Carcinoma
Cessation of Life
Literature
Neoplasm Metastasis
Protein Expression
Follow-up
Chaubardiella pubescens
Response to Epidermal Growth Factor Stimulus

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

The Canadian Journal of Plastic Surgery = Journal Canadien De Chirurgie Plastique
Nima P Patel, A Lawrence Cervino
Journal of the American Academy of Dermatology
M A Goldenhersh, T G Olsen
The Australasian Journal of Dermatology
A M GodboltDavid Weedon
Head & Neck Surgery
J S McDonaldJ L Gluckman
© 2021 Meta ULC. All rights reserved