Keratoacanthoma: facts and controversies

Clinics in Dermatology
Christine J Ko

Abstract

The keratoacanthoma and its variants are clinically and histologically heterogenous. Some consider the keratoacanthoma to be benign, whereas others classify it as a subtype of squamous cell carcinoma. The keratoacanthoma is generally treated rather than observed for spontaneous resolution. This hampers evaluation of the true natural history of lesions diagnosed as keratoacanthoma. In addition, studies have not found a reliable marker to differentiate keratoacanthoma from squamous cell carcinoma. It currently remains unclear how the keratoacanthoma relates to squamous cell carcinoma, and continued investigation is necessary.

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Related Concepts

Squamous Cell Carcinoma
Differential Diagnosis
Keratoacanthoma
Remission, Spontaneous
Malignant Neoplasm of Skin
Biological Markers
Evaluation
Subtype (Attribute)
Study

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