Keratoacanthoma: facts and controversies

Clinics in Dermatology
Christine J Ko


The keratoacanthoma and its variants are clinically and histologically heterogenous. Some consider the keratoacanthoma to be benign, whereas others classify it as a subtype of squamous cell carcinoma. The keratoacanthoma is generally treated rather than observed for spontaneous resolution. This hampers evaluation of the true natural history of lesions diagnosed as keratoacanthoma. In addition, studies have not found a reliable marker to differentiate keratoacanthoma from squamous cell carcinoma. It currently remains unclear how the keratoacanthoma relates to squamous cell carcinoma, and continued investigation is necessary.


Jan 1, 1975·Archives of Dermatology·J Rapaport
Jan 1, 1979·The British Journal of Dermatology·A Rook, I Whimster
Jan 1, 1979·Oncology·R A Schwartz
Mar 1, 1975·The Journal of Dermatologic Surgery·M D ChaletA B Ackerman
Oct 1, 1992·The American Journal of Dermatopathology·E Calonje, E W Jones
May 11, 1991·British Dental Journal·G HabelK Donath
Dec 1, 1990·Archives of Dermatology·H E TrowellD J Dyall-Smith
Nov 1, 1989·Archives of Dermatology·K L MageeK Adler-Storthz
Nov 1, 1988·Journal of the American Academy of Dermatology·Y D Eliezri, L Libow
Feb 1, 1972·Plastic and Reconstructive Surgery·N CohenM Loewenthal
Jun 1, 1968·Archives of Dermatology·R K Winkelmann, J Brown
Jun 1, 1984·Archives of Dermatology·J Kingman, J P Callen
Jan 1, 1983·British Journal of Plastic Surgery·I T JacksonC N Verheyden
Jul 1, 1980·Archives of Dermatology·N A Lapins, E B Helwig
Apr 1, 1980·The Australasian Journal of Dermatology·J J SullivanJ F McCaffrey
Oct 1, 1980·Journal of Cutaneous Pathology·W H Kern, M K McCray
Apr 1, 1994·Histopathology·K BlessingP M Gordon
Feb 1, 1997·The British Journal of Dermatology·R G DufresneL Robinson-Bostom
Oct 10, 1998·The British Journal of Dermatology·R Baran, S Goettmann
Nov 12, 1998·Journal of the American Academy of Dermatology·S Letzel, H Drexler
Aug 18, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·M AgarwalR Walia
Dec 11, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·B CribierE Grosshans
Apr 29, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·T A TranJ A Carlson
May 3, 2000·The British Journal of Dermatology·J E ConsigliS Maldonado
Aug 8, 2001·The Australasian Journal of Dermatology·A M GodboltDavid Weedon
Jan 18, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Perkins MukunyadziBruce R Smoller
Dec 18, 2002·The Journal of Investigative Dermatology·Ole Petter F ClausenPaula M de Angelis
Jan 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nicole D MelendezMichael Morgan
Jul 16, 2003·Journal of Cutaneous Pathology·Ola ForslundOle Petter F Clausen
Jul 1, 1954·Cleveland Clinic Quarterly·P SKIRPAN, J R HASERICK
Mar 23, 2004·Journal of Dermatological Science·Eiko IchikawaShinichi Watanabe
Feb 5, 2005·Blood·Rein WillemzeChris J L M Meijer
Jun 3, 2005·Clinical Medicine & Research·Ilene B Bayer-GarnerJaime A Tschen
May 27, 2006·The Journal of Investigative Dermatology·Ole Petter F ClausenPaula M DeAngelis
Jun 20, 2006·Pathology, Research and Practice·Tanja BatinacGordana Zauhar
Sep 6, 2006·Journal of Dermatological Science·Tanja BatinacGordana Zauhar
Jun 8, 2007·The Journal of Investigative Dermatology·Mariella D'AlessandroE Birgitte Lane
Aug 4, 2007·Pathology, Research and Practice·Kiriaki AroniEfstratios Patsouris
Oct 4, 2007·International Journal of Dermatology·Andrew G Affleck
Nov 3, 2007·Journal of Cutaneous Pathology·Nicolas KlugerFrançoise Plantier
Nov 17, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·Yoshiyuki ItoHitoshi Mizutani
Nov 21, 2007·Archives of Dermatology·Joe A ChornyJoel L Cohen
Mar 25, 2008·The American Journal of Dermatopathology·Steven KossardCarolyn Choy
Jul 1, 1950·The British Journal of Dermatology and Syphilis·M GRZYBOWSKI


Apr 25, 2013·JAAPA : Official Journal of the American Academy of Physician Assistants·Jessica Cosenza
Nov 6, 2012·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Brooke MohrJennifer Krejci-Manwaring
Oct 15, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Christopher M WolfeKaitlyn N Mula
Nov 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Patrick A OberholzerLevi A Garraway
Mar 5, 2013·The Oncologist·Mario E LacoutureAndrew K Joe
Oct 14, 2014·Diseases·Katherine N Gibson-CorleyDavid K Meyerholz
Jul 17, 2012·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Tom Jones, Manuel Blanco-Guzman
Oct 22, 2011·Clinics in Dermatology·Jennifer L DePryJerry D Brewer
Jun 2, 2015·Stem Cell Reports·Kailin R MesaValentina Greco
Feb 22, 2013·The Journal of Investigative Dermatology·Laura M RogersAdam J Dupuy
Jul 23, 2013·International Journal of Dermatology·Mhair S DekmezianJaime A Tschen
Sep 13, 2014·Clinical and Experimental Dermatology·R H El-KhayatS E Hoey
Jan 27, 2012·Actas dermo-sifiliográficas·A J González-RodríguezE Jordá-Cuevas
Nov 14, 2015·Journal of the American Society of Nephrology : JASN·Matthew J BottomleyKathryn J Wood
Jun 9, 2016·The Australasian Journal of Dermatology·Senhong LeeAnastasios Stavrakoglou
Jun 11, 2016·The Journal of Investigative Dermatology·Young H LimChristine J Ko
Mar 4, 2017·The Journal of Dermatology·Toshihiro Takai
May 10, 2012·Anais Brasileiros De Dermatologia·Maria Leonor Enei Gahona, Carlos d' Aparecida Santos Machado Filho
Feb 27, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·T GambichlerL Schmitz
Aug 1, 2015·Archives of Craniofacial Surgery·Hyochun ParkHyeonjung Yeo
Oct 12, 2018·Journal of Clinical Pathology·Christine J KoJean-Christophe Bourdon
Jan 2, 2020·Journal of Cutaneous Pathology·Priyadharsini Nagarajan
Jul 5, 2019·La Radiologia medica·Masaya KawaguchiMasayuki Matsuo
Oct 18, 2015·Experimental Dermatology·Tobias GleichDaniel Hohl
Apr 13, 2019·Head and Neck Pathology·Efthimios SivridisAlexandra Giatromanolaki
Oct 6, 2012·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Petter GjersvikStein Bergan
Jan 5, 2021·The American Journal of Dermatopathology·Alexander NirenbergAnthony Dixon

Related Concepts

Squamous Cell Carcinoma
Differential Diagnosis
Remission, Spontaneous
Malignant Neoplasm of Skin
Biological Markers
Subtype (Attribute)

Related Feeds


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.