Keratoacanthoma of the Nasal Septum Secondary to Ranibizumab Use

Case Reports in Pathology
Jason E CohnKenneth Briskin


Keratoacanthoma (KA) is a benign epithelial tumor that typically presents as a firm, cone-shaped, flesh-colored nodule with a central horn-filled crater. KA is considered to be a low-grade variant of squamous cell carcinoma (SCC). We report a rare case of a 72-year-old male who presented with a KA involving the nasal septum, possibly related to ranibizumab use. A flesh-colored lesion on the right anterior nasal septum lesion was visualized on examination. Histologic examination revealed a well-circumscribed, dome-shaped central crater filled with keratin, well-differentiated squamous epithelium with ground-glass cytoplasm with pushing margins, and intraepithelial microabscesses establishing the diagnosis of KA. KA of the nasal septum has only been reported once in the literature. This case is unusual because it normally presents on sun-exposed areas. Additionally, this patient was taking ranibizumab, a vascular endothelial growth factor (VEGF) inhibitor for macular degeneration. Despite ranibizumab not being directly linked to precancerous and cancerous skin lesions, agents in this medication class have been. Although it is difficult to prove associations in this isolated case, the role of ranibizumab causing cutaneous lesions ...Continue Reading


Sep 1, 1990·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B A EdelmanR Auerbach
Feb 1, 1985·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·F E Lucente
Jan 1, 1994·Journal of the American Academy of Dermatology·R A Schwartz
Feb 1, 1997·The American Journal of Dermatopathology·E D HsiT S Frank
Feb 13, 2003·Journal of the American Academy of Dermatology·Sean F Pattee, Nancy G Silvis
Jan 22, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·María P Valencia, Mauricio Castillo
Jul 15, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean Philippe ArnaultCaroline Robert
Aug 25, 2009·Journal of the American Academy of Dermatology·Eun Ji KwonChristine Jaworsky
Oct 17, 2009·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Gottfried WozelMichael P Schön
Feb 5, 2010·Pakistan Journal of Biological Sciences : PJBS·N YazdaniA Kouhi
Jun 8, 2010·Head & Face Medicine·Michael SandFalk G Bechara
May 14, 2011·Clinical and Experimental Dermatology·F BrowneG Stables
Feb 5, 2013·Clinical Ophthalmology·John B ChristoforidisHeather Powell
Jun 7, 2013·The American Journal of Dermatopathology·Paul N BognerNathalie C Zeitouni
Jan 17, 2015·Journal of the American Academy of Dermatology·James B MacdonaldAleksandar Sekulic
May 25, 2016·American Journal of Rhinology & Allergy·Ayse Pelin YigiderCemal Cingi

Related Concepts

Squamous Cell Carcinoma
Skin Lesion
Age Related Macular Degeneration

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Journal of Clinical and Diagnostic Research : JCDR
Saakshi GulatiAnita Balan
The International Journal of Lower Extremity Wounds
Manish BansalShyam Sunder Pandey
International Journal of Clinical and Experimental Medicine
Fei DengYingbo Dai
Pakistan Journal of Biological Sciences : PJBS
N YazdaniA Kouhi
Journal of Oral and Maxillofacial Pathology : JOMFP
Pooja KamathSubraj Shetty
© 2021 Meta ULC. All rights reserved