Abstract
The controversy of distinguishing keratoacanthomas (KAs) from well-differentiated squamous cell carcinomas (WDSCCs) is well established. A number of recent studies have attempted to separate these processes with the use of immunohistochemical stains. In corroboration, we have retrospectively reviewed three groups of patients with tissue biopsies with features of classical KA (n = 7), WDSCC (n = 8), and squamous cell carcinoma with KA-like features (SCC-KA) (n = 9). We compared their clinical and histological differences as well as their immunohistochemical differences using antibodies to proliferating cell nuclear antigen (PCNA), and wild- and mutant-type p53 protein. Classical KA showed a PCNA staining pattern located predominantly around the basal cell layers, in contrast to a relatively diffuse staining pattern seen in WDSCC. SCC-KA showed considerable overlap with these two types of staining patterns. The p53 staining showed basal, patchy, or diffuse patterns. These patterns were present in all three groups. Although both PCNA and p53 expression was more often present in SCC-KA, there were no statistical differences among the groups. In conclusion, the overlapping expression patterns of PCNA and p53 in keratocanthoma-like t...Continue Reading
Citations
Jul 1, 1997·Journal of Cutaneous Pathology·W WeningerE Tschachler
May 26, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·Arash BordbarMathilde E Boon
Jul 7, 2007·International Journal of Dermatology·Amel Karaa, Amor Khachemoune
Jan 24, 2009·International Journal of Cancer. Journal International Du Cancer·Natasa VasiljevićOla Forslund
Nov 29, 2013·International Journal of Surgical Pathology·Phyu P AungMeera Mahalingam
Dec 1, 1996·Seminars in Cutaneous Medicine and Surgery·D Mehregan, D Mehregan
Jul 9, 2002·The British Journal of Dermatology·C M DobsonC M King
May 12, 2010·Clinical and Experimental Dermatology·M HonmaH Iizuka
Sep 3, 2013·Hand : Official Journal of the American Association for Hand Surgery·Timothy P DooleyMark E Baratz
Jan 23, 2016·Case Reports in Pathology·Avani A Pendse, Siobhan M O'Connor
Oct 16, 2019·Indian Journal of Pathology & Microbiology·Gulay TuranOzgur Kulahci
Jul 10, 2001·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·R BaranS Goettmann-Bonvallot
Aug 19, 2000·The American Journal of Dermatopathology·E Sánchez YusE de Eusebio
Feb 12, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Robert A Schwartz
May 19, 2007·Clinical and Experimental Dermatology·T KanekuraN Yoshii
Apr 22, 2005·Veterinary Dermatology·Mariarita RomanucciLeonardo della Salda
Nov 7, 1999·Journal of Cutaneous Pathology·T A TranJ A Carlson
Jan 25, 2005·Clinical and Experimental Dermatology·A SinhaJ Langtry
Jan 5, 2006·Archives of Pathology & Laboratory Medicine·Emad KaabipourAnne-Marie Martin
Dec 15, 2007·Pathology, Research and Practice·Daniel RibeiroMariângela E A Marques