Keratocyte Density Is Reduced and Related to Corneal Nerve Damage in Diabetic Neuropathy

Investigative Ophthalmology & Visual Science
Alise KaltenieceRayaz A Malik

Abstract

The purpose of this study was to assess the relationship between corneal keratocyte density (KD) and corneal nerve damage in patients with and without diabetic peripheral neuropathy. Eighty-six patients with type 1 and type 2 diabetes and 21 age-matched control subjects underwent assessment of the neuropathy disability score, quantitative sensory testing, electrophysiology, and corneal confocal microscopy and were divided into those without (DN-) (n = 22) and with (DN+) (n = 64) diabetic neuropathy. Corneal sub-basal nerve parameters and KD in the anterior, mid, and posterior stroma were quantified. Anterior, mid, and posterior stromal KD were significantly reduced in DN- (P = 0.02, P = 0.009, P = 0.01, respectively) and DN+ (all P < 0.0001) subjects compared to controls. Corneal nerve branch density (CNBD) (P < 0.0001, P < 0.0001) and corneal nerve fiber length (CNFL) (P = 0.03, P < 0.0001) were significantly reduced in DN- and DN+ subjects, respectively, and corneal nerve fiber density (CNFD) (P < 0.0001) was significantly reduced only in DN+ subjects compared to controls. Anterior, mid, and posterior stromal KD correlated significantly with CNFD (P = 0.008, P = 0.005, P = 0.01), CNBD (P = 0.01, P = 0.006, P = 0.001), and CNF...Continue Reading

References

Oct 1, 1981·The British Journal of Ophthalmology·N BustedO Schmitz
May 1, 1995·Klinische Monatsblätter für Augenheilkunde·B E FruehM Böhnke
Apr 17, 2003·Experimental Eye Research·Linda J MüllerTimo M T Tervo
Aug 25, 2004·Investigative Ophthalmology & Visual Science·Panagiotis Kallinikos, Nathan Efron
Sep 29, 2004·Investigative Ophthalmology & Visual Science·Anders IvarsenTorben Møller-Pedersen
Oct 27, 2004·Investigative Ophthalmology & Visual Science·Martha P CalvilloWilliam M Bourne
May 6, 2006·The International Journal of Biochemistry & Cell Biology·Judith A West-Mays, Dhruva J Dwivedi
Oct 28, 2006·Cornea·Maria João QuadradoJaap A Van Best
Jan 21, 2011·Journal of Visualized Experiments : JoVE·Mitra Tavakoli, Rayaz A Malik
Feb 22, 2011·Journal of Cataract and Refractive Surgery·Derek W DelMonte, Terry Kim
May 1, 1986·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·B A HoldenN Efron
Oct 15, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·G BitirgenH Kerimoglu
Jul 7, 2015·Progress in Retinal and Eye Research·Keith M Meek, Carlo Knupp
Mar 30, 2017·Scientific Reports·Gary Hin-Fai YamJodhbir S Mehta
Apr 14, 2017·Vision Research·Alexander V Ljubimov

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Citations

Oct 1, 2019·Current Eye Research·Bhavani S Kowtharapu, Oliver Stachs
May 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Beida RenQingguo Wang
Jan 22, 2021·Investigative Ophthalmology & Visual Science·Zohaib IqbalHandrean Soran
Jan 25, 2021·Experimental Eye Research·Ruchi ShahAlexander V Ljubimov
May 23, 2020·Experimental Eye Research·Gary H F YamVishal Jhanji
May 5, 2021·Investigative Ophthalmology & Visual Science·Luca D'OnofrioRayaz A Malik

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