Ketamine administration disturbs behavioural and distributed neural correlates of fear conditioning in the rat

Progress in Neuro-psychopharmacology & Biological Psychiatry
Charmaine Y PietersenJ A den Boer

Abstract

The neurotransmitter glutamate and its associated receptors perform an important role in the brain circuitry underlying normal fear processing. The glutamate NMDA receptor, in particular, is necessary for the acquisition and recollection of conditioned-fear responses. Here the authors examine how acute blockage of the NMDA receptor with sub-anaesthetic doses of ketamine affects behavioural assays of fear-conditioned stress (e.g. freezing) and cFos expression in a network of brain areas that have previously been implicated in fear processing. Fear-conditioned rats displayed significantly more freezing behaviour than non-conditioned controls. In fear-conditioned rats that also received ketamine, this conditioning effect was largely neutralised. Fear conditioning also led to increased cFos expression in various areas central to fear processing, including the basolateral nucleus of the amygdala, the paraventricular nucleus of the hypothalamus and the anterior cingulate. Ketamine abolished such increases in cFos expression in most brain areas investigated. The present study therefore demonstrates that systemic ketamine administration in rats interferes with fear conditioning on a behavioural level and in a network of brain regions a...Continue Reading

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Citations

Dec 27, 2007·PloS One·Charmaine Y PietersenJohan A den Boer
Dec 3, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Adam StewartAllan V Kalueff
Nov 4, 2015·Pharmacology, Biochemistry, and Behavior·Caitlin M Groeber TravisRaymond F Genovese
Apr 21, 2012·Brain Research Bulletin·Aron TulogdiJózsef Haller
Jul 6, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Fokko J BoskerGerard te Meerman
Sep 15, 2012·Physiology & Behavior·Jonathan J SabbaghJefferson W Kinney
Jan 18, 2018·Journal of Psychopharmacology·Nicholas E CliftonJeremy Hall
Nov 5, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jefferson P GalvanhoYael Abreu-Villaça
Mar 30, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lanwei HouLin Sun
Dec 18, 2020·Neurobiology of Learning and Memory·Maria MorenaPatrizia Campolongo
Jan 27, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gabriela P SiloteVanessa Beijamini

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