Ketamine aggravates symptoms of acute stress disorder in a naturalistic sample of accident victims

Journal of Psychopharmacology
M SchönenbergM Hautzinger

Abstract

The glutamatergic N-methyl-D-aspartate receptor antagonist ketamine produces transient dissociative states and alters cognitive functioning in healthy humans, thus resembling the core symptoms of acute and chronic post-traumatic stress disorder (PTSD). First evidence exists that the common use of the analgesic and sedative properties of ketamine during emergency care correlates with sustained symptoms of PTSD in accident victims. The aim of the present study was to examine whether ketamine administration after moderate accidental trauma modulates dissociation and other symptoms of acute stress disorder (ASD) in the direct aftermath of the event. Accident victims were screened within the third day after admission to hospital for symptoms of ASD (Peritraumatic Dissociative Experiences Questionnaire, ASD Scale) and prior stressful life events (Traumatic Life Events Questionnaire). Subjects had received a single or fractionated dose of either racemic ketamine (n=13), opioids (n=24) or non-opioid analgesics (n=13) during initial emergency treatment. There were no significant differences between medication groups in demographic and clinical characteristics such as injury severity or prior traumatization. With respect to ASD symptomat...Continue Reading

References

Oct 1, 1996·Behaviour Research and Therapy·K A BartonE J Hickling
Feb 1, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·F X VollenweiderJ Angst
May 20, 1999·Biological Psychiatry·M A HertzbergJ R Davidson
Aug 15, 2001·Journal of the American Academy of Child and Adolescent Psychiatry·G SaxeL King
Jan 31, 2003·Psychological Bulletin·Emily J OzerDaniel S Weiss
Dec 1, 2004·The American Journal of Psychiatry·Hermann Winter, Eva Irle

❮ Previous
Next ❯

Citations

Jun 19, 2013·PloS One·Philip R CorlettPaul C Fletcher
Jul 28, 2012·Expert Opinion on Investigational Drugs·Christopher K CainJohn H Kehne
May 28, 2013·Biological Psychiatry·Daniel D'Andrea, R Andrew Sewell
Jul 15, 2015·Journal of Trauma & Dissociation : the Official Journal of the International Society for the Study of Dissociation (ISSD)·Basant PradhanTapan Parikh
Jul 17, 2012·Annales Françaises D'anesthèsie Et De Rèanimation·G Mion
Oct 6, 2009·Clinical Psychology Review·Judith CukorBarbara O Rothbaum
Nov 19, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Alzbeta Juven-WetzlerJoseph Zohar
Jan 1, 2014·Social Work in Mental Health·Bryan LubomirskyMarijo B Tamburrino
May 20, 2016·Current Psychiatry Reports·Faryal Mallick, Cheryl B McCullumsmith
Jan 28, 2017·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Josephine C McGowanChristine A Denny
Jan 31, 2019·Annual Review of Clinical Psychology·Lauren A M LeboisKerry J Ressler
Dec 25, 2019·Drug Metabolism and Personalized Therapy·Alireza JalaliMaryam Bahreini
Sep 1, 2017·Clinical Psychology : a Publication of the Division of Clinical Psychology of the American Psychological Association·Benjamin KelmendiJohn H Krystal
Dec 18, 2020·Neurobiology of Learning and Memory·Maria MorenaPatrizia Campolongo
Jan 27, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gabriela P SiloteVanessa Beijamini
Apr 21, 2020·Pharmacology & Therapeutics·Brenda Sbarski, Irit Akirav
Apr 17, 2021·Neurochemistry International·Muhammad AsimXiaoguang Wang
Jul 9, 2009·Current Opinion in Anaesthesiology

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.