Ketamine and midazolam delivered by patient-controlled analgesia in relieving pain associated with burns dressings

The Clinical Journal of Pain
Ross D MacPhersonJoanna Penfold

Abstract

A study involving the use of a mixture of ketamine and midazolam delivered via patient-controlled analgesia (PCA) device was trialed to assess its effectiveness in reducing pain associated with repeated burns dressings in an adult population. Patients undergoing burns dressings changes were given a PCA device of ketamine and midazolam to use during the procedure. The aims were to investigate the efficacy of the device and to ascertain what (if any) adverse effects were associated with its use. During the trial period, 44 patients who underwent 95 separate procedures were enrolled. The effectiveness of the device was rated (out of 10) by both staff and patients with the mean scores being 8.47 and 8.50, respectively. In all but 1 case, the proposed procedure was carried out successfully. Thirteen patients reported a total of 23 adverse effects, with hallucinations (11) being the most common. The use of ketamine/midazolam delivered by PCA was shown to be an effective means of pain control during burns dressings as assessed by both staff and patients. The incidence of adverse events was low.

Associated Clinical Trials

References

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Citations

Dec 25, 2010·Der Anaesthesist·R Girtler, B Gustorff
Jul 11, 2009·The Clinical Journal of Pain·Dilek DilliNihan H Sorguç
Jul 11, 2009·The Clinical Journal of Pain·Ross MacPherson
Sep 2, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Siobhan K McGuinnessPatrick D Mahar
Jun 10, 2009·Burns : Journal of the International Society for Burn Injuries·P Richardson, L Mustard
Jan 22, 2011·Paediatric Anaesthesia·Michelle C WhitePeter A Stoddart
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Sep 11, 2016·Burns : Journal of the International Society for Burn Injuries·Mathieu FontaineFrançois Ravat
Sep 14, 2011·Journal of Burn Care & Research : Official Publication of the American Burn Association·Michele M GottschlichRichard J Kagan
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Oct 17, 2017·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Michael MorganIrina Vetter
Jul 9, 2009·Current Opinion in Anaesthesiology

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