Ketamine as a promising prototype for a new generation of rapid-acting antidepressants

Annals of the New York Academy of Sciences
Chadi G AbdallahJohn H Krystal

Abstract

The discovery of ketamine's rapid and robust antidepressant effects opened a window into a new generation of antidepressants. Multiple controlled trials and open-label studies have demonstrated these effects across a variety of patient populations known to often achieve little to no response from traditional antidepressants. Ketamine has been generally well tolerated across patient groups, with transient mild-to-moderate adverse effects during infusion. However, the optimal dosing and route of administration and the safety of chronic treatment are not fully known. This review summarizes the clinical effects of ketamine and its neurobiological underpinnings and mechanisms of action, which may provide insight into the neurobiology of depression, relevant biomarkers, and treatment targets. Moreover, we offer suggestions for future research that may continue to advance the field forward and ultimately improve the psychopharmacologic interventions available for those individuals struggling with depressive and trauma-related disorders.

References

Aug 21, 1990·European Journal of Pharmacology·R Trullas, P Skolnick
Feb 25, 2000·Biological Psychiatry·R M BermanJ H Krystal
Jun 29, 2002·Anesthesia and Analgesia·Akira KudohTomoko Takazawa
Jun 19, 2003·JAMA : the Journal of the American Medical Association·Ronald C KesslerUNKNOWN National Comorbidity Survey Replication
Nov 25, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Martin M KatzAlan Frazer
Apr 25, 2006·Biological Psychiatry·Ronald S Duman, Lisa M Monteggia
Aug 9, 2006·Archives of General Psychiatry·Carlos A ZarateHusseini K Manji
May 8, 2007·Urology·Rohan ShahaniRobert J Stewart
Oct 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Houman Homayoun, Bita Moghaddam
Feb 6, 2008·Archives of General Psychiatry·J F William DeakinSerdar M Dursun
Sep 12, 2009·The Journal of Clinical Psychiatry·Rodrigo Machado-VieiraCarlos A Zarate
Nov 3, 2009·Psychiatric Services : a Journal of the American Psychiatric Association·Bradley N GaynesA John Rush
Feb 9, 2010·Psychiatry Research·Bernhard T BauneDavid Mitchell
Apr 16, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giacomo SalvadoreCarlos A Zarate
Aug 4, 2010·Archives of General Psychiatry·Nancy DiazgranadosCarlos A Zarate
Sep 16, 2010·Nature Reviews. Neuroscience·Giles E Hardingham, Hilmar Bading
Dec 18, 2010·Journal of Affective Disorders·Bo Jacob HasselbalchLars Vedel Kessing
Apr 7, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Lobna IbrahimCarlos A Zarate
May 12, 2011·The International Journal of Neuropsychopharmacology·Gregory Luke Larkin, Annette L Beautrais
Jul 8, 2011·Nature·Pamela Y CollinsDan J Stein
Aug 13, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Samuel A NeymotinWilliam W Lytton
Nov 2, 2011·The International Journal of Neuropsychopharmacology·Giacomo SalvadoreCarlos A Zarate
Dec 1, 2011·Nature Reviews. Neuroscience·Maurizio PopoliGerard Sanacora
Feb 3, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lobna IbrahimCarlos A Zarate
Apr 17, 2012·Biological Psychiatry·Pierre BlierJean Blier
Jun 9, 2012·The International Journal of Neuropsychopharmacology·Wallace C DuncanCarlos A Zarate
Jun 19, 2012·Biological Psychiatry·Marije Aan Het RotSanjay J Mathew

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Citations

Apr 10, 2015·International Journal of Molecular Sciences·Kenji Hashimoto
Jan 3, 2016·Progress in Neurobiology·Rodrigo Machado-VieiraCarlos A Zarate
Dec 22, 2015·Current Opinion in Neurobiology·Nolan R Williams, Alan F Schatzberg
Mar 31, 2016·Clinical Pharmacokinetics·Marko A PeltoniemiTeijo I Saari
Apr 12, 2016·Depression and Anxiety·Chadi G AbdallahJohn H Krystal
Mar 11, 2015·Annals of the New York Academy of Sciences·Kenneth A JonesDigavalli V Sivarao
Aug 19, 2015·Biochemical and Biophysical Research Communications·Tomasz BoczekLudmila Zylinska
Jun 25, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael R WeedLinda J Bristow
Jul 14, 2016·Acta Neuropsychiatrica·Xi-Cong LiuAleksander A Mathé
Aug 30, 2016·Neuropharmacology·Karolina PodkowaAgnieszka Pałucha-Poniewiera
Aug 24, 2016·Expert Opinion on Drug Discovery·Miguel Reyes-Parada, Patricio Iturriaga-Vasquez
Dec 3, 2016·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Dian-Jeng LiPao-Yen Lin
Sep 1, 2016·Brain Structure & Function·Anna HöflichRupert Lanzenberger
Jun 10, 2017·Expert Review of Neurotherapeutics·Gopalkumar RakeshPrakash S Masand
Feb 22, 2018·Harvard Review of Psychiatry·Dawn F IonescuThilo Deckersbach
Sep 15, 2018·Annual Review of Pharmacology and Toxicology·Chadi G AbdallahJohn H Krystal
Feb 25, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chadi G AbdallahJohn H Krystal
May 7, 2020·Reviews in the Neurosciences·Rebecca McMillan, Suresh D Muthukumaraswamy
Nov 29, 2015·Neurotoxicity Research·Yousef Tizabi
Aug 31, 2016·Current Behavioral Neuroscience Reports·Dawn F Ionescu, George I Papakostas
Jan 15, 2019·European Journal of Psychotraumatology·Teddy J AkikiChadi G Abdallah
Jul 1, 2020·International Psychogeriatrics·Aarti GuptaRajesh R Tampi
Mar 23, 2017·Translational Psychiatry·D F Ionescu, G I Papakostas
May 12, 2017·Neural Plasticity·Yu-Jhen HuangChieh-Hsin Lin
Aug 31, 2019·Pharmacology & Therapeutics·Simone B Sartori, Nicolas Singewald
Dec 5, 2020·Brain Sciences·Matthew B PhillipsJon W Johnson
Feb 17, 2021·Molecular Psychiatry·Ioannis MantasPer Svenningsson
Nov 16, 2018·Journal of Affective Disorders·Gustavo KinrysMaurizio Fava

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