Ketamine, but not propofol, anaesthesia is regulated by metabotropic glutamate 5 receptors

British Journal of Anaesthesia
J-H SouH-H Chen

Abstract

Group I metabotropic glutamate receptors (mGluRs) have been reported to regulate N-methyl-d-aspartate (NMDA) receptor function in various brain regions. The selective mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) can potentiate NMDA antagonists such as PCP and MK-801-induced behavioural responses. In the present study, the role of group I mGluRs on ketamine- and propofol-induced general anaesthesia was examined. Mice were pretreated with various doses of the group I mGluR agonist (S)-3,5-dihydroxyphenylglycine (DHPG), selective mGluR5 agonist (RS)-2-chloro-5-hydroxyphenylglycine (CHPG), mGluR1 antagonist 7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester (CPCCOEt) and mGluR5 antagonist MPEP followed by administration of ketamine (120 mg kg(-1)) or propofol (140 mg kg(-1)) to induce anaesthesia. The duration of loss of righting reflex was recorded. DHPG and CHPG antagonized and MPEP potentiated ketamine-induced anaesthesia in a dose-dependent manner. CPCCOEt was ineffective. However, propofol-induced anaesthesia was not affected after manipulating mGluR1 and mGluR5 receptors. mGluR5 receptors play an important role in modulation of anaesthesia induced by ketamine, but not propofol.

References

Dec 1, 1986·Journal of Pharmacological Methods·S E Laursen, J K Belknap
Jan 26, 1996·Neuroscience Letters·S M FitzjohnG L Collingridge
Nov 14, 1997·Journal of Neurophysiology·F M Zhou, J J Hablitz
Nov 19, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joyce Besheer, Clyde W Hodge

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Citations

Mar 4, 2008·Psychopharmacology·Ming-Huan ChanHwei-Hsien Chen
Jul 27, 2010·Pharmacogenetics and Genomics·Chris DowningThomas E Johnson
Feb 14, 2012·Schizophrenia Research·Ming-Huan ChanHwei-Hsien Chen
Apr 8, 2010·European Journal of Pharmacology·Anne Lesage, Thomas Steckler
Oct 3, 2012·Pharmacology, Biochemistry, and Behavior·Ming-Huan ChanHwei-Hsien Chen
Nov 20, 2016·Neurotoxicology and Teratology·Changsheng LiRoger A Johns
Nov 9, 2007·Behavioural Pharmacology·Elizabeth L van der KamThomas M Tzschentke
Mar 3, 2020·Frontiers in Systems Neuroscience·Dana Baron ShahafGoded Shahaf
Jul 11, 2007·Current Opinion in Anaesthesiology

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