Abstract
Individuals with stress-related psychiatric disorders exhibit deficits in cognitive flexibility. We have shown that chronic intermittent cold stress induces deficits in reversal learning, a form of cognitive flexibility mediated in the orbitofrontal cortex, that was reversed by ketamine in male rats. Such effects have not been tested in females. In this study, we examined effects of chronic intermittent cold stress and ketamine on reversal learning in females. Female Sprague-Dawley rats underwent 14 days of chronic intermittent cold and 3 days later received an injection of ketamine (10 mg/kg, i.p.). They were tested on reversal learning 24 hours post-injection. A separate cohort of female rats underwent 14 days of chronic intermittent cold. Three days later they received ketamine and were killed 2 hours post-injection for measurement of the synaptic marker PSD95 in orbitofrontal cortex. Chronic intermittent cold induced a reversal learning deficit in females comparable with that seen in males, which was corrected by ketamine. Moreover, chronic intermittent cold increased PSD95 expression in orbitofrontal cortex, but this increase was not seen in rats receiving ketamine. Chronic intermittent cold stress and ketamine altered rev...Continue Reading
References
Nov 1, 1991·Endocrinology·V Viau, M J Meaney
Apr 1, 1996·Pharmacology, Biochemistry, and Behavior·A SfikakisD Tsakayannis
Oct 8, 1997·Neuroscience·L A GaleaF S Dhabhar
Feb 11, 2000·The Annals of Pharmacotherapy·E J FrackiewiczN R Cutler
Aug 21, 2002·Stress : the International Journal on the Biology of Stress·Victoria Luine
Sep 6, 2002·Pharmacology, Biochemistry, and Behavior·Q David WalkerCynthia M Kuhn
Mar 5, 2003·Hormones and Behavior·Rachel E BowmanVictoria N Luine
Jun 19, 2003·JAMA : the Journal of the American Medical Association·Ronald C KesslerUNKNOWN National Comorbidity Survey Replication
May 7, 2005·Metabolism: Clinical and Experimental·Rudolf E Noble
Jul 28, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Conor ListonBruce S McEwen
Jul 1, 2008·Psychopharmacology·M Danet S Lapiz-BluhmDavid A Morilak
Jul 11, 2009·Expert Review of Neurotherapeutics·Benji T KurianMadhukar H Trivedi
Aug 21, 2010·Science·Nanxin LiRonald S Duman
Jan 23, 2013·Neuropharmacology·Nicole Carrier, Mohamed Kabbaj
Mar 10, 2016·Biological Psychiatry·Ambalika Sarkar, Mohamed Kabbaj
Oct 18, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael S PattonMilena Girotti