Ketamine Strengthens CRF-Activated Amygdala Inputs to Basal Dendrites in mPFC Layer V Pyramidal Cells in the Prelimbic but not Infralimbic Subregion, A Key Suppressor of Stress Responses

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Rong-Jian LiuGeorge Aghajanian

Abstract

A single sub-anesthetic dose of ketamine, a short-acting NMDA receptor blocker, induces a rapid and prolonged antidepressant effect in treatment-resistant major depression. In animal models, ketamine (24 h) reverses depression-like behaviors and associated deficits in excitatory postsynaptic currents (EPSCs) generated in apical dendritic spines of layer V pyramidal cells of medial prefrontal cortex (mPFC). However, little is known about the effects of ketamine on basal dendrites. The basal dendrites of layer V cells receive an excitatory input from pyramidal cells of the basolateral amygdala (BLA), neurons that are activated by the stress hormone CRF. Here we found that CRF induces EPSCs in PFC layer V cells and that ketamine enhanced this effect through the mammalian target of rapamycin complex 1 synaptogenic pathway; the CRF-induced EPSCs required an intact BLA input and were generated primarily in basal dendrites. In contrast to its detrimental effects on apical dendritic structure and function, chronic stress did not induce a loss of CRF-induced EPSCs in basal dendrites, thereby creating a relative imbalance in favor of amygdala inputs. The effects of ketamine were complex: ketamine enhanced apical EPSC responses in all mPF...Continue Reading

References

Feb 25, 2000·Biological Psychiatry·R M BermanJ H Krystal
Nov 7, 2000·The Journal of Comparative Neurology·K Van PettP E Sawchenko
Jul 22, 2004·Journal of Neurobiology·Susan C Cook, Cara L Wellman
Jul 29, 2006·Science·Noelia V WeisstaubJay A Gingrich
Jun 26, 2007·Biological Psychiatry·Mounira BanasrRonald S Duman
Jan 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Rong-Jian Liu, George K Aghajanian
Jul 22, 2008·Biological Psychiatry·Mounira Banasr, Ronald S Duman
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Joseph L Price, Wayne C Drevets
Oct 22, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Demetrio Sierra-MercadoGregory J Quirk
Dec 17, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chantelle J GiesbrechtWilliam F Colmers
Apr 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael L Lehmann, Miles Herkenham
Jan 17, 2012·The Journal of Comparative Neurology·Paul GabbottSarah Busby
Oct 9, 2012·Science·Ronald S Duman, George K Aghajanian
Feb 20, 2013·The Journal of Physiology·Roger MarekPankaj Sah
Mar 29, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mallika PadivalJ Amiel Rosenkranz
Jan 1, 2012·Frontiers in Neural Circuits·Lital Bar-IlanIdan Segev
Jun 4, 2013·Biological Psychiatry·John H KrystalRonald S Duman
Jul 24, 2013·Annals of the New York Academy of Sciences·Carlos ZarateHarald Murck
Sep 27, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Justin P Little, Adam G Carter
Oct 9, 2013·The International Journal of Neuropsychopharmacology·Herbert Y MeltzerMasakuni Horiguchi
Dec 3, 2013·Neuron·Jun-Hyeong ChoVadim Y Bolshakov
Mar 14, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vincent VialouEric J Nestler

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Citations

Apr 12, 2016·Depression and Anxiety·Chadi G AbdallahJohn H Krystal
Oct 21, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rong-Jian LiuRonald S Duman
Sep 13, 2017·Brain Injury : [BI]·Rasoul RezaeiGhorbangol Ashabi
Dec 5, 2019·The International Journal of Neuropsychopharmacology·Hector E YarurKatia Gysling
Aug 28, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Manoela V FogaçaRonald S Duman
Jun 17, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Oliver VranjkovicDanny G Winder
Mar 27, 2020·Psychiatry Investigation·Cheolmin Shin, Yong-Ku Kim
Apr 1, 2021·Life Sciences·Máira Tereza Talma ChíricoRodrigo Cunha Alvim de Menezes
Nov 21, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yael S GrossmanDani Dumitriu

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