Ketamine suppresses both bicuculline- and picrotoxin-induced generalized tonic-clonic seizures during ontogenesis

Pharmacology, Biochemistry, and Behavior
J VelískováR Rokyta

Abstract

An anticonvulsant action of ketamine, a noncompetitive N-methyl-D-aspartate (NMDA) antagonist (5-40 mg/kg IP), on the bicuculline-induced (3-8 mg/kg IP) or picrotoxin-induced seizures (3-6 mg/kg IP) was assessed in male Wistar rats aged 7, 12, 18, 25 and 90 days. Ketamine alone caused moderate ataxia which was more pronounced in younger animals. In combination with both aforementioned convulsants, ketamine exerted anticonvulsant effects against generalized tonic-clonic seizures in all developmental stages studied. This effect was more pronounced in bicuculline-treated animals. Moreover, ketamine also suppressed the lethality induced by both drugs during all the development. On the contrary, the action of ketamine on minimal (clonic) seizures was moderate or absent. Our results suggest an important role of ketamine-affected transmission in the generation of the generalized tonic-clonic seizure pattern; moreover, an action of high doses of ketamine on GABA-A receptors might be present.

References

Nov 1, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·S N GlissonB C Bloor
Feb 1, 1989·Pharmacology, Biochemistry, and Behavior·L VelísekP Mares
Sep 1, 1987·Epilepsy Research·M Pohl, P Mares
Aug 29, 1986·Neuroscience Letters·R J Brady, J W Swann
Feb 1, 1986·Behavioural Brain Research·A P LecceseJ E Moreton
Oct 29, 1985·European Journal of Pharmacology·B A Hayes, R L Balster
Oct 1, 1983·Pharmacological Research Communications·W M BournJ N Davisson
Jan 1, 1981·Pharmacology, Biochemistry, and Behavior·M S MyslobodskyM Mintz

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Citations

Nov 1, 1992·Naunyn-Schmiedeberg's Archives of Pharmacology·L VelisekR Schickerova
Feb 1, 1995·Italian Journal of Neurological Sciences·L VelísekS L Moshé
Sep 1, 1992·Pharmacology, Biochemistry, and Behavior·J Velísková, L S Velísek
Apr 1, 1993·Pharmacology, Biochemistry, and Behavior·J VelískováD Micianiková
Aug 1, 1993·Pharmacology, Biochemistry, and Behavior·L VelísekP Mares
Nov 1, 1995·Pharmacology, Biochemistry, and Behavior·H Kubová, P Mares
Jun 19, 1992·Brain Research. Developmental Brain Research·W TurskiE A Cavalheiro
Aug 12, 1994·Brain Research. Developmental Brain Research·R MikolásováP Mares
Mar 10, 2004·Pharmacology, Biochemistry, and Behavior·Cheryl J SchindlerIlona Vathy
Jun 6, 2000·Brain Research. Developmental Brain Research·C J SchindlerI Vathy
Jul 28, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·I Vathy
Jan 1, 1997·Epilepsy Research·C E StafstromG L Holmes
Mar 18, 2006·BMC Neuroscience·Tamaki HayaseKeiichi Yamamoto
Jan 3, 2013·Neurochemistry International·Patricia Graciela Schneider, Georgina Rodríguez de Lores Arnaiz
Apr 19, 2007·Brain Research·Jana TchekalarovaPavel Mares
Apr 23, 2013·CNS Neuroscience & Therapeutics·Frederic DorandeuGuy Testylier
Oct 2, 2012·Toxicology and Applied Pharmacology·Michael P ShakarjianLibor Velíšek
Feb 5, 2014·Neurobiology of Disease·Fredrik BerglindMerab Kokaia
Nov 8, 2011·Epilepsy & Behavior : E&B·Mehdi Ghasemi, Steven C Schachter
Jul 8, 2016·Annals of the New York Academy of Sciences·Michael P ShakarjianLibor Velíšek
Jul 1, 1996·The International Journal of Neuroscience·N R Krenz, R M Cooper
Mar 11, 1998·Chronobiology International·P SubramanianE Balamurugan
Jul 26, 2005·The International Journal of Neuroscience·Gulen GulerAdem Boyaci
Oct 31, 2002·Chronobiology International·M RebueltoR Bonafine
Apr 22, 2021·Seizure : the Journal of the British Epilepsy Association·Christian Lizette Frías-SoriaLuisa Rocha

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