Ketanserin in the treatment of Raynaud's phenomenon associated with generalized scleroderma

The British Journal of Dermatology
M Engelhart

Abstract

The efficacy of the 5-HT-2-receptor antagonist, ketanserin, in the treatment of Raynaud's phenomenon was assessed in a double-blind, placebo-controlled, crossover trial in nine patients with generalized scleroderma (GS). Each patient received ketanserin 20 mg or placebo three times a day in the 1st week and 40 mg ketanserin or placebo three times a day for the remaining 4 weeks, and was then crossed over for 5 weeks. Measurements were made of finger blood pressure and flow during a cold challenge test and patients recorded numbers of Raynaud's attacks. No significant improvement was found in reactions to cold provocation or in numbers of Raynaud's attacks during ketanserin treatment, but intolerable side-effects were common. Interactions with concomitant medication might be a possible explanation for this. We conclude that ketanserin in the dose given, is not effective in the treatment of Raynaud's phenomenon in GS.

Citations

Apr 5, 2002·Arthritis and Rheumatism·Maria Kyriakidi, John P A Ioannidis
Jan 10, 2009·Clinical Reviews in Allergy & Immunology·Vasiliki Kalliopi K BourniaM Eric Gershwin
Nov 1, 1990·International Journal of Dermatology·I GhersetichT Lotti
Nov 1, 1996·Rheumatic Diseases Clinics of North America·A Deswal, W P Follansbee
May 5, 2000·The Cochrane Database of Systematic Reviews·J PopeA Silman
Jul 1, 1991·International Journal of Dermatology·E Tur

Related Concepts

Clinical Trials
Double-Blind Method
R-41,468
Raynaud Phenomenon
Systemic Scleroderma

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