Ketoconazole in vitro inhibits mitogen-induced blastogenesis, antibody-dependent cellular cytotoxicity, natural killer activity and random migration of human leukocytes

Immunopharmacology
P GergelyA Perl

Abstract

Ketoconazole at concentrations of 1-10 micrograms/ml dose dependently inhibits mitogen-induced blastogenesis, antibody-dependent and spontaneous cytotoxic (natural killer) activity of human lymphocytes and random migration of human leukocytes. Lectin-dependent cytotoxic activity is not affected by the drug.

References

Jan 1, 1977·International Archives of Allergy and Applied Immunology·D I GroveK S Warren
Jan 21, 1978·British Medical Journal·Y H Thong, B Rowan-Kelly
Apr 15, 1975·International Journal of Cancer. Journal International Du Cancer·M Jondal, H Pross
Sep 1, 1970·Cellular Immunology·P Perlmann, H Perlmann
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·H Host
Jan 1, 1981·Scandinavian Journal of Immunology·I LángG Petrányi
Jun 1, 1980·Antimicrobial Agents and Chemotherapy·H Van den BosscheJ M van Cutsem
Sep 1, 1982·Annals of Internal Medicine·A PontD A Stevens
Feb 1, 1983·Annals of Internal Medicine·P C CravenB E Levine
Jan 1, 1983·The Journal of Antimicrobial Chemotherapy·C E van RensburgH A Eftychis
Sep 17, 1982·Journal of Immunological Methods·L Kalmár, P Gergely

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Citations

Jan 1, 1990·International Journal of Immunopharmacology·V VuddhakulY H Thong
Aug 1, 1992·International Journal of Immunopharmacology·M CoolsJ Van Wauwe
Feb 16, 2020·Archives of Toxicology·Frank FasbenderCarsten Watzl
Jan 1, 1989·The Journal of Urology·T EichenbergerA Keating
Jan 1, 1988·Immunopharmacology and Immunotoxicology·G PéterY Kaneko

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