PMID: 11746421Dec 18, 2001

Ketogenic diet, amino acid metabolism, and seizure control

Journal of Neuroscience Research
Marc YudkoffIlana Nissim

Abstract

The ketogenic diet has been utilized for many years as an adjunctive therapy in the management of epilepsy, especially in those children for whom antiepileptic drugs have not permitted complete relief. The biochemical basis of the dietary effect is unclear. One possibility is that the diet leads to alterations in the metabolism of brain amino acids, most importantly glutamic acid, the major excitatory neurotransmitter. In this review, we explore the theme. We present evidence that ketosis can lead to the following: 1) a diminution in the rate of glutamate transamination to aspartate that occurs because of reduced availability of oxaloacetate, the ketoacid precursor to aspartate; 2) enhanced conversion of glutamate to GABA; and 3) increased uptake of neutral amino acids into the brain. Transport of these compounds involves an uptake system that exchanges the neutral amino acid for glutamine. The result is increased release from the brain of glutamate, particularly glutamate that had been resident in the synaptic space, in the form of glutamine. These putative adaptations of amino acid metabolism occur as the system evolves from a glucose-based fuel economy to one that utilizes ketone bodies as metabolic substrates. We consider m...Continue Reading

References

May 13, 2005·Neurochemistry International·Marc YudkoffItzhak Nissim
Feb 11, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Marc YudkoffItzhak Nissim
Feb 11, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Tim E Cullingford
Aug 31, 2006·Behavioural Pharmacology·Maciej GasiorAdam L Hartman
May 12, 2006·The Neurologist·Panayiotis N Varelas, Marianna Spanaki
Aug 2, 2005·Epilepsy Currents·Carl E Stafstrom
Apr 21, 2007·Annual Review of Nutrition·Marc YudkoffItzhak Nissim
Apr 15, 2011·Critical Care : the Official Journal of the Critical Care Forum·Hayden White, Balasubramanian Venkatesh
Dec 1, 2012·Journal of Epilepsy Research·Mi-Sun YumDong Wook Kim
Jan 19, 2010·Annual Review of Pathology·Douglas C WallaceVincent Procaccio
Jul 5, 2011·Brain & Development·Mi-Sun YumDong Wook Kim
Feb 5, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Alberto Julio-AmilpasLourdes Massieu
Mar 19, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maggie RoyAnne-Karine Bouzier-Sore
Apr 10, 2007·Epilepsy Research·Kristopher J BoughRaymond Dingledine
Jan 24, 2007·Epilepsia·Kristopher J Bough, Jong M Rho
Nov 30, 2004·Neuroscience Research·Denize R ZieglerCarlos-Alberto Gonçalves
Oct 8, 2004·Brain Research. Molecular Brain Research·Hae Sook NohWan Sung Choi
Sep 3, 2004·Brain Research Bulletin·Marina LeiteCarlos-Alberto Gonçalves
Mar 3, 2006·Neurochemistry International·Marc YudkoffItzhak Nissim
Aug 2, 2005·Epilepsy & Behavior : E&B·Madeline E RhodesCheryl A Frye
Mar 6, 2003·Neurologic Clinics·Raj D Sheth, Carl E Stafstrom
May 2, 2003·Nutritional Neuroscience·Carl E Stafstrom, Kristopher J Bough
May 31, 2012·Nutritional Neuroscience·Mao NagasawaMitsuhiro Furuse
Dec 24, 2013·Neuropharmacology·Sachiko ChikahisaHiroyoshi Séi
Dec 7, 2010·Neurobiology of Aging·Robert KrikorianDeborah J Clegg

Citations

Feb 2, 1979·Brain Research·M D Norenberg, A Martinez-Hernandez
Apr 1, 1978·Annals of Neurology·D C DeVivoD B McDougal
Nov 1, 1975·The American Journal of Physiology·A Gjedde, C Crone
Jan 1, 1976·The American Journal of Physiology·W H Oldendorf, J Szabo
Mar 1, 1976·The American Journal of Physiology·T J MooreD M Regen
Jun 8, 1992·Neuroscience Letters·H CarlsonL Hillered
Mar 1, 1992·The Journal of Clinical Investigation·R R Russell, H Taegtmeyer
Mar 1, 1991·Journal of Neurochemistry·H J FlavinThomas N Seyfried
Apr 1, 1990·Journal of Neurochemistry·G Battaglioli, D L Martin
Aug 1, 1989·Journal of Neurochemistry·Marc YudkoffM Erecińska
Feb 15, 1986·The Biochemical Journal·Marc YudkoffD Pleasure
Jan 1, 1987·Journal of Neurochemistry·T G Porter, D L Martin
Sep 1, 1988·Journal of Neurochemistry·M ErecińskaMarc Yudkoff
Oct 1, 1988·Journal of Neurochemistry·A TovarA E Harper
May 1, 1988·Journal of Neurochemistry·A J Cheeseman, J B Clark
Aug 1, 1988·The American Journal of Physiology·J T Tildon, L M Roeder
Nov 1, 1987·Journal of Neurochemistry·Q R SmithS I Rapoport
Jun 1, 1974·Epilepsia·D B Appleton, D C DeVivo
Jul 16, 1971·Biochemical and Biophysical Research Communications·G Benns, P Proulx
Feb 1, 1972·Archives of Biochemistry and Biophysics·J T Tildon, D A Sevdalian
Dec 1, 1971·The American Journal of Physiology·W H Oldendorf
Oct 1, 1967·The Journal of Clinical Investigation·O E OwenG F Cahill
Jan 1, 1980·Journal of Neuroscience Research·M Pollay, F A Stevens
May 1, 1983·Pharmacology, Biochemistry, and Behavior·A W MahoneyD V Sisson
Jan 1, 1980·Physiological Reviews·A M Robinson, D H Williamson
May 1, 1995·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K SatoR L Veech
Jan 1, 1995·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·G F MasonE J Novotny

Related Concepts

Metabolic Process, Cellular
Amino Acid Metabolism
Oxaloacetates
Keto Acids
Aspartate
Epilepsy
Acclimatization
Amino Acids, I.V. solution additive
Energy Metabolism
Brain

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Related Papers

Journal of Neuroscience Research
Marc YudkoffIlana Nissim
Advances in Experimental Medicine and Biology
Michelle A PuchowiczJoseph C LaManna
Prostaglandins, Leukotrienes, and Essential Fatty Acids
Marc YudkoffItzhak Nissim
Pediatric Neurology
Adam L HartmanMichael A Rogawski
© 2020 Meta ULC. All rights reserved