Ketogenic Diet and microRNAs Linked to Antioxidant Biochemical Homeostasis

Antioxidants
Roberto CannataroErika Cione

Abstract

Recently, we demonstrated the capability of the ketogenic diet (KD) to influence the microRNA (miR) expression profile. Here, we report that KD is able to normalize miR expression in obese subjects when compared with lean subjects. By applying two different bioinformatics tools, we found that, amongst the miRs returning to comparable levels in lean subjects, four of them are linked to antioxidant biochemical pathways specifically, and the others are linked to both antioxidant and anti-inflammatory biochemical pathways. Of particular interest is the upregulation of hsa-miR-30a-5p, which correlates with the decrease of catalase expression protein in red blood cells.

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Citations

Dec 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Erika CioneLuca Gallelli
Apr 4, 2021·Antioxidants·Llion Arwyn Roberts, Katsuhiko Suzuki
Jul 3, 2021·Journal of Functional Morphology and Kinesiology·Roberto CannataroErika Cione

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Methods Mentioned

BETA
Assay

Software Mentioned

GraphPad
GraphPad Prism
DIANA
miRtagertLink Human

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