Ketogenic diet effects on 52 children with pharmacoresistant epileptic encephalopathy: A clinical prospective study

Brain and Behavior
Qiong WuYing Qi

Abstract

To evaluate the clinical impact of ketogenic diet (KD) on children with pharmacoresistant epileptic encephalopathy. In all, 52 children with pharmacoresistant epileptic encephalopathy that diagnosed in our hospital from July 2012 to June 2015 were selected, including West syndrome 38 cases, Lennox-Gastaut Syndrome 7 cases, Doose Syndrome 1 case, and Dravet syndrome 6 cases, and the effect, compliance, adverse reactions, electroencephalogram (EEG), and cognitive function were analyzed. Modified Johns Hopkins protocol was used to initiate KD, and Engel scale was used to evaluate the effect, and evaluated the effect of KD on the cognition, language, and motor function. At 12 weeks of KD treatment, the patients achieved I, II, III, and IV grade effect were accounted for 26.9% (14/52 cases), 17.3% (9/52 cases), 11.5% (6/52 cases), and 44.2% (23/52 cases), respectively, according to Engel scale. KD has different effect on different epileptic syndromes, best effect on Doose syndromes of 100%, and better effect on West syndrome with the effect rate of 57.9%, and the total effect number was 22 cases. The reduction of epileptiform discharges in the awake state before KD treatment was correlated with the seizure time after 3 months of KD ...Continue Reading

References

Mar 7, 1996·The New England Journal of Medicine·J Engel
Feb 1, 2005·Epilepsia·Eric H Kossoff, Jane R McGrogan
Jun 15, 2007·Epilepsia·Roberto CantelloFrancesco Monaco
Jul 11, 2007·Journal of Child Neurology·Christian KorffDouglas Nordli
Aug 5, 2008·Seizure : the Journal of the British Epilepsy Association·Amnon MosekNachum Vaisman
Nov 27, 2008·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Beth A Zupec-Kania, Emily Spellman
Dec 17, 2008·Epilepsia·Eric H Kossoff, Jennifer L Dorward
Mar 17, 2009·Brain Research·Yuka SuzukiEiichi Ishii
Apr 29, 2009·Annals of Neurology·Carl E StafstromThomas P Sutula
Jun 19, 2009·Journal of Child Neurology·Eric H KossoffJong M Rho
Aug 15, 2009·Journal of Child Neurology·Mary L Zupanc
Jul 6, 2010·Seizure : the Journal of the British Epilepsy Association·Anastasia DresslerMartha Feucht
Feb 25, 2011·Epilepsy Research·Sudha Kilaru KesslerA G Christina Bergqvist
Jun 3, 2011·Epilepsy Research·A G Christina Bergqvist
Aug 30, 2011·Epilepsy Research·Tove HallböökBronwen Martin
Jun 14, 2012·Acta Neurologica Scandinavica·D A J E LambrechtsM J M Majoie
May 9, 2013·Journal of Child Neurology·Linda Laux, Robyn Blackford
May 23, 2015·Expert Review of Neurotherapeutics·Steven Parrish WinesettEric H W Kossoff
Jul 30, 2016·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Elles van der LouwJ Helen Cross

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Citations

Apr 25, 2019·Expert Review of Clinical Pharmacology·Krista Eschbach, Kelly G Knupp
Oct 14, 2018·Current Treatment Options in Neurology·Julie ZiobroKelly G Knupp
Oct 6, 2020·Frontiers in Pharmacology·Luis Felipe Santos MenezesElisabeth Ferroni Schwartz
Oct 27, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Emine TekinHaydar Ali Taşdemir
Dec 21, 2020·Seizure : the Journal of the British Epilepsy Association·Lin WanLiping Zou
Apr 20, 2021·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Indar Kumar SharawatLesa Dawman
Jul 28, 2020·Seizure : the Journal of the British Epilepsy Association·Yan-Qiu WangLi Jiang

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