Ketogenic diet exhibits neuroprotective effects in hippocampus but fails to prevent epileptogenesis in the lithium-pilocarpine model of mesial temporal lobe epilepsy in adult rats

Epilepsia
Benjamin LinardEmmanuel Raffo

Abstract

Although the number of antiepileptic drugs (AEDs) is increasing, none displays neuroprotective or antiepileptogenic properties that could prevent status epilepticus (SE)-induced drug-resistant epilepsy. Ketogenic diet (KD) and calorie restriction (CR) are proposed as alternative treatments in epilepsy. Our goal was to assess the neuroprotective or antiepileptogenic effect of these diets in a well-characterized model of mesial temporal lobe epilepsy following initial SE induced by lithium-pilocarpine in adult rats. Seventy-five P50 male Wistar rats were fed a specific diet: normocalorie carbohydrate (NC), hypocalorie carbohydrate (HC), normocalorie ketogenic (NK), or hypocalorie ketogenic (HK). Rats were subjected to lithium-pilocarpine SE, except six NC to constitute a control group for histology (C). Four rats per group were implanted with epidural electrodes to record electroencephalography (EEG) during SE and the next six following days. From the seventh day, the animals were video-recorded 10 h daily to determine latency to epilepsy onset. Neuronal loss in hippocampus and parahippocampal cortices was analyzed 1 month after the first spontaneous seizure. After lithium-pilocarpine injection, neither KD nor CR modified SE feat...Continue Reading

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Citations

Oct 16, 2012·Epilepsia·Katja KobowJong M Rho
Sep 21, 2013·Expert Opinion on Drug Discovery·Barbara MiziakStanisław J Czuczwar
Feb 10, 2016·Frontiers in Cellular Neuroscience·Jorge Landgrave-GómezRosalinda Guevara-Guzmán
Aug 11, 2015·Neuropharmacology·Theresa A LusardiDetlev Boison
Aug 23, 2011·Epilepsy Research·Liu Lin Thio
May 27, 2015·Epilepsia·Nina DupuisStéphane Auvin
Mar 31, 2015·Frontiers in Cellular Neuroscience·Bryan V Phillips-FarfánKarla G Carvajal Aguilera
Apr 6, 2017·The Journal of Pathology·Xin XuXuefeng Wang
Dec 18, 2018·Frontiers in Neurology·Clarissa F CavarsanLuciene Covolan
Oct 18, 2018·Nature Reviews. Cancer·Alessio NencioniValter D Longo
Oct 21, 2017·Pharmaceuticals·Chiara LucchiGiuseppe Biagini
Aug 22, 2018·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alexandra ClémentFatiha Maskali
May 14, 2011·Current Opinion in Pediatrics

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