Ketogenic diet in migraine: rationale, findings and perspectives

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Piero BarbantiMassimiliano Caprio

Abstract

Ketogenic diet (KD) is an established treatment for refractory pediatric epilepsy and a promising therapy for diverse neurological diseases. Clinical data on KD in migraine-obtained from 150 patients investigated in case reports and prospective studies-suggest that KD may be a rapid onset effective prophylaxis for episodic and chronic migraine. KD would contribute to restore brain excitability and metabolism and to counteract neuroinflammation in migraine, although its precise mechanism is still unclear. Randomized controlled studies are needed to confirm the usefulness of KD in migraine and to investigate its optimal duration, repeatability, feasibility in normal weight subjects, efficacy in pediatric population and association to conventional migraine prophylaxis.

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Citations

Oct 11, 2017·Antioxidants & Redox Signaling·Patrizia FerroniFiorella Guadagni
Aug 11, 2018·Journal of Child Neurology·Jasna JancicJanko Samardzic
Jan 13, 2018·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ilaria Di Donato, Antonio Federico
Feb 19, 2020·Expert Review of Neurotherapeutics·Marco Lisicki, Jean Schoenen
Jun 23, 2020·Expert Opinion on Therapeutic Targets·Jo NijsAnneleen Malfliet
Jun 23, 2018·Current Medicinal Chemistry·Sabina CevoliPietro Cortelli
Aug 4, 2018·International Journal of Molecular Sciences·Brian A ParkerBenjamin T Bikman
Aug 14, 2020·Eating and Weight Disorders : EWD·Masoume MansouriOmid Sadeghi
Sep 19, 2018·Nutrients·Valentina A AndreevaPilar Galan
Oct 31, 2019·Journal of Translational Medicine·Giovanna MuscogiuriAnnamaria Colao
Sep 19, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Tanya J W McDonald, Mackenzie C Cervenka
Aug 23, 2020·Nutrients·Simona DraganRuxandra Christodorescu
Feb 3, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Daria BongiovanniMaurizio Fadda
Feb 20, 2021·Frontiers in Neurology·Umberto RaucciPasquale Parisi
Jun 3, 2021·Life·Olivia GrechAlexandra J Sinclair
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