Ketogenic Diet-Induced Severe Ketoacidosis in a Lactating Woman: A Case Report and Review of the Literature

Case Reports in Nephrology
Benedicta Nneoma NnodumMark Pettus

Abstract

The ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that leads to nutritional ketosis and weight loss. It is known to induce ketosis but is not an established cause of clinically significant ketoacidosis. Lactation ketoacidosis is well established in bovine literature but remains a rare phenomenon in humans. Here we present a life-threatening case of severe ketoacidosis in a nondiabetic lactating mother on a strict ketogenic diet. We review the available case reports of lactation ketoacidosis in humans and the mechanisms thereof. Although ketogenic diet has been shown to be safe in nonpregnant individuals, the safety of this diet in lactating mothers is not known. Health professionals and mothers should be made aware of the potential risk associated with a strict ketogenic diet when combined with lactation. Prompt diagnosis and immediate treatment cannot be overemphasized. To our knowledge, this is the first reported case of life-threatening lactation ketoacidosis associated with ketogenic diet while consuming an adequate number of calories per day.

References

Jan 1, 1982·Diabetes Care·B ChernowJ T O'Brian
Dec 1, 1996·Zentralblatt für Veterinärmedizin. Reihe A·P Holtenius, K Holtenius
Feb 15, 2007·European Journal of Clinical Nutrition·W S YancyE C Westman
Nov 3, 2007·The Journal of Emergency Medicine·Alan C Heffner, David P Johnson
Apr 24, 2009·The American Journal of Clinical Nutrition·Mahmoud A MohammadMorey W Haymond
Aug 6, 2009·American Journal of Physiology. Endocrinology and Metabolism·Mahmoud A MohammadMorey W Haymond
Jun 27, 2013·European Journal of Clinical Nutrition·A PaoliK A Grimaldi
Feb 22, 2014·International Journal of Environmental Research and Public Health·Antonio Paoli
Apr 29, 2015·La Revue de médecine interne·D MonnierB Fantin
Aug 1, 2009·NDT Plus·Harminder S SandhuMaria V DeVita
Jun 17, 2016·A & a Case Reports·David J Greaney, Pat Benson
Sep 16, 2017·Endocrine·Diego Gomez-ArbelaezFelipe F Casanueva
Sep 20, 2017·Endocrinology, Diabetes & Metabolism Case Reports·Gordon SloanJonathan Webster
Oct 13, 2017·Journal of Postgraduate Medicine·L GuptaS Aggarwal

❮ Previous
Next ❯

Citations

Feb 5, 2021·Frontiers in Cellular Neuroscience·Maude BordeleauMarie-Ève Tremblay
Apr 12, 2021·Nursing for Women's Health·Megan W ArbourJudith C Wika

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Anaesthesiology
Michelle S Chew, Lina Dalesjö
The Journal of the Indiana State Medical Association
P Altus, J W Hickman
Canadian Family Physician Médecin De Famille Canadien
Rhonda TingAdrienne J Lindblad
© 2021 Meta ULC. All rights reserved