Ketogenic therapy in neurodegenerative and psychiatric disorders: From mice to men.

Progress in Neuro-psychopharmacology & Biological Psychiatry
Ann-Katrin KraeuterZoltán Sarnyai

Abstract

Ketogenic diet is a low carbohydrate and high fat diet that has been used for over 100 years in the management of childhood refractory epilepsy. More recently, ketogenic diet has been investigated for a number of metabolic, neurodegenerative and neurodevelopmental disorders. In this comprehensive review, we critically examine the potential therapeutic benefits of ketogenic diet and ketogenic agents on neurodegenerative and psychiatric disorders in humans and translationally valid animal models. The preclinical literature provides strong support for the efficacy of ketogenic diet in a variety of diverse animal models of neuropsychiatric disorders. However, the evidence from clinical studies, while encouraging, particularly in Alzheimer's disease, psychotic and autism spectrum disorders, is limited to case studies and small pilot trials. Firm conclusion on the efficacy of ketogenic diet in psychiatric disorders cannot be drawn due to the lack of randomised, controlled clinical trials. The potential mechanisms of action of ketogenic therapy in these disorders with diverse pathophysiology may include energy metabolism, oxidative stress and immune/inflammatory processes. In conclusion, while ketogenic diet and ketogenic substances h...Continue Reading

Citations

Aug 11, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Shebani Sethi DalaiAshley N Gearhardt
Aug 11, 2020·Current Opinion in Endocrinology, Diabetes, and Obesity·Nicholas G NorwitzChristopher M Palmer
Aug 28, 2020·Frontiers in Psychiatry·Barbara ScolnickThomas Hildebrandt
Mar 2, 2021·Frontiers in Psychiatry·Nicholas G Norwitz, Uma Naidoo
Sep 18, 2021·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Rowena FieldKieron Rooney

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