Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma

Biochemical and Biophysical Research Communications
Wenbo GaoChunhai Su

Abstract

Many studies have pinpointed that fructose could be utilized as a carbon source in some cancers, and we also defined that glioma cells could utilize fructose to maintain themselves survival and proliferation depending on GLUT5 expression recently. However, ketohexokinase (KHK), as a key enzyme involved in fructose catabolism, drew less attention in cancers, especially in glioma. In the present study, we first analyzed the expression levels of KHK in glioma tissues and the correlations of KHK expression with clinicopathological variables of patients with glioma. Meanwhile, we detected the effect of silencing KHK on the biological functions of glioma cells in fructose medium. From the results, we found that KHK was expressed at significantly higher level in glioma tissues than in non-tumor brain, and KHK expression was significantly correlated with tumor malignancy and poor survival of glioma patients (p < 0.01). Functionally, knockdown of KHK could significantly inhibit cell proliferation and migration of glioma cells in fructose medium. Furthermore, we investigated the KHK expression level after long-time treatment with fructose, and detected the change of cell biological behaviour, then we found that the expression level of KH...Continue Reading

Citations

Jul 17, 2020·Cancer & Metabolism·Takahiko NakagawaRichard J Johnson
Jan 12, 2021·Frontiers in Oncology·Erick Andrés Muciño-OlmosOsbaldo Resendis-Antonio
Feb 2, 2021·Trends in Endocrinology and Metabolism : TEM·Carolina EcheverríaAlejandro S Godoy
Dec 12, 2020·Cells·Nils Krause, Andre Wegner
Mar 26, 2021·Cancer & Metabolism·Roger J LiangMarcus D Goncalves
Jul 3, 2021·Frontiers in Cell and Developmental Biology·Runze QiuHongwei Fan
Aug 10, 2021·Clinical Medicine Insights. Oncology·Linchen LiXinjun Wang

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