Ketone body metabolism in the Carp Cyprinus carpio: biochemical and 1H NMR spectroscopical analysis

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
H SegnerR Böhm

Abstract

In fed and starved carp, Cyprinus carpio, ketone body metabolism and those metabolic and endocrine factors that are known to induce ketogenesis in starving mammals were investigated. Acetoacetate was detected in plasma and liver of both fed and starved carp. We could not detect 3-hydroxybutyrate, neither by 1H-NMR spectroscopy nor by spectrophotometric assay, in spite of low activities of hepatic 3-hydroxybutyrate dehydrogenase. Starvation of carp did not create metabolic conditions that would favor ketone body synthesis: Mobilization and hepatic catabolism of fatty acids were only moderately enhanced, the rate of gluconeogenesis was not elevated, and glucagon levels as well as the glucagon/insulin-ratio remained stable or declined. Therefore, the discrepancy in the effect of food deprivation on mammalian and teleostean ketogenesis appears to be caused not by the absence of the ketogenic pathway from teleosts but by major differences between mammals and fish in their metabolic response to starvation.

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Citations

Jan 10, 2012·Fish Physiology and Biochemistry·A Pérez-JiménezA E Morales
Apr 18, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·José L Soengas, Manuel Aldegunde
Apr 5, 2005·Toxicologic Pathology·Jeffrey C Wolf, Marilyn J Wolfe
Dec 19, 2001·The Journal of Experimental Zoology·L J MagnoniJ L Soengas
Jan 12, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Marshall D McCue
Oct 14, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Ben Speers-Roesch, Jason R Treberg
Jul 5, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Natasha Therese FrickJames Stuart Ballantyne
Jan 25, 2000·The Journal of Biological Chemistry·M F OleksiakD C Zeldin
Nov 7, 2013·The Journal of Endocrinology·David A BaltzegarRussell J Borski
Apr 13, 2010·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·K SalinF Hervant

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