Ketonuria may be associated with low serum amylase independent of body weight and glucose metabolism

Archives of Physiology and Biochemistry
Kei Nakajima, Eiji Oda

Abstract

Ketonuria, which reflects a preferential combustion of lipids relative to carbohydrates, is often observed in lean rather than obese people. Clinical studies have shown that individuals with diabetes and/or obesity predispose to have low serum amylase (LSA). To investigate the association between ketonuria and LSA. We examined ketonuria assessed by dipstick urinalysis and clinical parameters including serum amylase in 3638 Japanese people aged 25-79 years who underwent a health-screening checkup. There was an inverse relationship between body mass index (BMI) and serum amylase. The lowest serum amylase was observed in obese subjects (BMI ≥ 25.0 kg/m(2)) with positive ketonuria. Logistic regression analysis showed that ketonuria was significantly associated with LSA (<50 IU/L), which was not altered by the adjustments for relevant confounders including age, sex, BMI, and HbA1c. Current results suggest a relative unavailability of carbohydrates for energy production in individuals with LSA.

References

Nov 1, 1974·The American Journal of Clinical Nutrition·H Mohammadiha
Jan 15, 2000·Diabetes/metabolism Research and Reviews·L Laffel
Aug 28, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·Z ZamanN Barba
Jun 23, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A SwislockiG Triadafilopoulos
Oct 29, 2005·Metabolism: Clinical and Experimental·Esther ViceHisham A Barakat
Aug 17, 2006·Pediatric Diabetes·Francesco PriscoPaolo Pozzilli
Jun 15, 2007·Obesity·Jane E FerrieMika Kivimäki
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Apr 17, 2009·Obesity·Maarten R SoetersMireille J Serlie
Apr 19, 2011·Cardiovascular Diabetology·Kei NakajimaHiromi Munakata
Jan 24, 2014·The American Journal of Clinical Nutrition·Jane E WinterCaryl A Nowson
Jan 25, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Ying ZhaoYu Chen
Apr 2, 2014·Nature Genetics·Mario FalchiPhilippe Froguel
Feb 20, 2012·Journal of Diabetes Investigation·Atsunori KashiwagiUNKNOWN Committee on the Standardization of Diabetes Mellitus‐Related Laboratory Testing of Japan Diabetes Society
May 23, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·Y-J ChoiJ W Yun
Jun 21, 2016·Diabetes Research and Clinical Practice·Jenny Pena DiasStephanie Studenski

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