PMID: 8951933Oct 1, 1996Paper

Ketoprofen produces profound inhibition of spinal c-Fos protein expression resulting from an inflammatory stimulus but not from noxious heat

Pain
J BuritovaJ M Besson

Abstract

This study assesses the anti-inflammatory/analgesic effects of ketoprofen a non-steroidal anti-inflammatory drug, using the method of c-Fos immunoreactivity at the spinal cord level in two models of noxious stimulation: carrageenan-induced inflammatory pain or acute noxious heat. Ketoprofen was pre-administered intravenously or orally 25 min before an intraplantar injection of carrageenan (6 mg in 150 microliters of saline) in hindpaw of the non-anaesthetised rat or before a single noxious heat (52 degrees C, 15 sec) stimulation of hindpaw of the anaesthetised rat. Three hours after carrageenan or 2 h after noxious heat, the number of spinal c-Fos protein-like immunoreactive (c-Fos-LI) neurons in L4-L5 segments and both the ankle and paw diameter, the indicator of peripheral oedema, were assessed. Pre-administered ketoprofen (1, 3 and 10 mg/kg i.v.) dose-dependently blocks the development of the carrageenan-induced spinal c-Fos protein expression and peripheral oedema, with the highest dose influencing in parallel both parameters (75 +/- 2% diminution of total number of c-Fos-LI neurons per L4-L5 section; 64 +/- 4% and 82 +/- 6% diminution of paw and ankle oedema, respectively). The effect of ketoprofen was significantly greate...Continue Reading

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Citations

Mar 3, 2007·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Hang ZhaoSatoshi Kashimoto
May 15, 2002·European Journal of Pharmacology·Jaroslava Buritova, Jean-Marie Besson
Jan 20, 1998·Brain Research Bulletin·J A Harris
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Dec 17, 2008·BMC Musculoskeletal Disorders·Bunji TakayamaMiho Sekiguchi
Jul 29, 2003·Journal of Magnetic Resonance Imaging : JMRI·Krisztina L MaliszaAnthony Wright
Nov 29, 2011·Journal of Orthopaedic Science : Official Journal of the Japanese Orthopaedic Association·Sumihisa OritaSeiji Ohtori
Mar 5, 2008·European Journal of Pharmacology·Philippe GirardJean-Marie Gillardin
Dec 18, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·W A Prado, R M C Pontes

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