Ketorolac-based analgesia improves outcomes for living kidney donors

Transplantation
Stephen J FreedlandH Albin Gritsch

Abstract

To reduce the morbidity of living kidney donors we introduced ketorolac-based analgesia for patients undergoing open donor nephrectomy in August 1999. There are no prior reports on the use of ketorolac for patients undergoing donor nephrectomy. We conducted a retrospective review of all 198 consecutive patients who underwent open living donor nephrectomy between January 1998 and July 2000 at our institution. We compared patients who underwent surgery before and after introduction of ketorolac-based analgesia. The introduction of ketorolac-based analgesia resulted in a reduction in length of postoperative stay from 3.7+/-0.1 to 3.1+/-0.1 days (P<0.001). Patients who underwent surgery after ketorolac introduction required 58% less narcotics (P<0.001), recalled having less postoperative pain, and stopped taking pain medications sooner than patients before routine ketorolac use. Moreover, these patients drank 38% more liquids on the first postoperative day (P<0.001) and were able to resume a regular diet sooner than patients who were not managed with ketorolac. Patients who received ketorolac had a slightly lower creatinine clearance on the second postoperative day relative to patients who did not (66 vs. 72% of preoperative calcul...Continue Reading

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Citations

May 29, 2002·Urology·Stephen J FreedlandH Albin Gritsch
Nov 15, 2012·Pain Research and Treatment·U Mathuram ThiyagarajanM L Nicholson
Sep 12, 2006·The Surgical Clinics of North America·Paul E Morrissey, Anthony P Monaco
Sep 16, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jennifer S SingerPeter Schulam
May 12, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M H AndersenE Fosse
Sep 14, 2011·Transplantation Proceedings·E GorevskiJ Martin-Boone
Feb 22, 2005·BJU International·John M Barry
Dec 28, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jeffrey CampsenRobin D Kim
Jun 13, 2019·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Parissa TabrizianRon Shapiro
Jan 20, 2018·Current Urology Reports·Georges Nasrallah, Fouad G Souki
Dec 18, 2019·Korean journal of anesthesiology·Chang-Hoon Koo, Jung-Hee Ryu
Jun 9, 2021·Clinical Transplantation·Matthew H V ByrneMichael L Nicholson

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