Ketotherapy as an epigenetic modifier in cancer.

Reviews in Endocrine & Metabolic Disorders
Borja Bandera-MerchanFrancisco J Tinahones

Abstract

Epigenetic alterations in cancer play a variety of roles. Aberrant DNA methylation, as one of the epigenetic mechanisms, has been widely studied in both tumor and liquid biopsies and provide a useful bench mark for treatment response in cancer. Recently, several studies have reported an association between the type of diet and epigenetic modifications. Whereby there is a growing interest in finding the "anti-cancer diet formula", if such a thing exists. In this sense, ketogenic diets (KD) have reported potentially beneficial effects, which were able to prevent malignancies and decrease tumor growth. Some studies have even shown increased survival in cancer patients, reduced side effects of cytotoxic treatments, and intensified efficacy of cancer therapies. Although the biological mechanisms of KD are not well understood, it has been reported that KD may affect DNA methylation by modulating the expression of crucial genes involved in tumor survival and proliferation. However, there are many considerations to take into account to use ketotherapy in cancer, such as epigenetic mark, type of cancer, immunological and metabolic state or microbiota profile. In this review, we argue about ketotherapy as a potential strategy to consider...Continue Reading

References

Nov 5, 1999·Seminars in Cancer Biology·J G Herman
Mar 6, 2004·Cancer Metastasis Reviews·Yutaka Kondo, Jean-Pierre J Issa
Dec 20, 2005·Nutrition & Metabolism·John C MavropoulosEric C Westman
Apr 6, 2006·Cancer Causes & Control : CCC·Scott Davis, Dana K Mirick
Jan 8, 2008·The American Journal of Clinical Nutrition·Alexandra M JohnstoneGerald E Lobley
Oct 31, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·Stephen D HurstingSusan N Perkins
Oct 12, 2010·Advances in Genetics·Dajun DengYantao Du
Jun 28, 2011·Clinical Chemistry·Maria ChimonidouEvi S Lianidou
Jul 29, 2011·Nutrition & Metabolism·Melanie SchmidtUlrike Kämmerer
Nov 9, 2011·Chinese Journal of Cancer·Xiao-Tong Hu, Chao He
Nov 25, 2011·Nature Reviews. Cancer·Melin J KhandekarBruce M Spiegelman
Dec 7, 2011·Drugs·Sang-Hyun SongYung-Jue Bang
Aug 6, 2013·Nutrition and Cancer·Gordana SupicZvonko Magic
Jan 21, 2014·Cell Metabolism·Valter D Longo, Mark P Mattson
Jan 31, 2014·Current Neurology and Neuroscience Reports·Irfan A Qureshi, Mark F Mehler
Feb 28, 2014·World Journal of Gastroenterology : WJG·Eiji SakaiAtsushi Kaneda
Mar 13, 2014·Pharmacotherapy·Padmaja Mummaneni, Stacy S Shord
May 28, 2014·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kim M SmitsPhilippe Lambin
Jun 5, 2014·Inflammatory Bowel Diseases·Jan Däbritz, Trevelyan R Menheniott
Sep 5, 2014·Journal of Cellular Biochemistry·Steven P Zielske
Oct 15, 2014·Journal of Cancer Research and Therapeutics·K C LakshmaiahSmitha C Saldanha
Nov 22, 2014·Human Reproduction Update·Ana B Crujeiras, Felipe F Casanueva
Dec 3, 2014·Redox Biology·Bryan G AllenMelissa A Fath
Dec 30, 2014·Nutrients·Michael A Conlon, Anthony R Bird
Aug 8, 2015·Journal of Cellular Biochemistry·Diane M JaworskiJohn R Moffett
Aug 26, 2015·Advances in Experimental Medicine and Biology·Machiko ShirahataEric W Kostuk
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert L Ferris
Sep 24, 2015·Expert Review of Molecular Diagnostics·Anna M JankowskaCharles W Caldwell
Oct 8, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A B CrujeirasF F Casanueva
Oct 20, 2015·Epigenomics·Pedro Costa-PinheiroCarmen Jerónimo
Feb 4, 2016·Food & Function·Kishore Vipperla, Stephen J O'Keefe
Feb 5, 2016·Cancer Letters·Ting Wu, Yun Dai
Feb 26, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·B CabiaA B Crujeiras
Mar 2, 2016·International Journal of Molecular Sciences·Víctor MicóLidia Daimiel
Mar 30, 2016·Annual Review of Nutrition·Carmen Sapienza, Jean-Pierre Issa
May 4, 2016·Molecular Nutrition & Food Research·Scott J Bultman
May 12, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Christopher Wright, Nicole L Simone
May 26, 2016·The British Journal of Nutrition·Gregory D M PotterLaura J Hardie
Aug 26, 2016·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·Sebastian Brandhorst, Valter D Longo
Sep 9, 2016·Annual Review of Microbiology·Caitlin A Brennan, Wendy S Garrett
Sep 16, 2016·Nature Reviews. Genetics·Peter A JonesStephen Baylin
Oct 25, 2016·Nature Reviews. Cancer·Adam KinnairdEvangelos D Michelakis

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Citations

Apr 30, 2021·British Journal of Cancer·Maria M RubinsteinNeil M Iyengar
Jul 8, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rainer J KlementReinhart A Sweeney

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