PMID: 6102487Feb 9, 1980

Ketotifen in adult asthma

British Medical Journal
A J Dyson, A D Mackay

Abstract

The efficacy and adverse effects of ketotifen 1 mg twice daily and 2 mg twice daily were compared with placebo in 50 patients with atopic asthma in a multicentre, double-blind study. Ketotifen in the higher dosage caused a slight reduction in salbutamol usage and a modest improvement in breathing in patients not already receiving inhaled corticosteroids. The drug was ineffective in patients receiving inhaled corticosteroids. Drowsiness was a troublesome effect causing withdrawal from treatment or reduction of dosage in seven patients while receiving ketotifen compared with only three while receiving placebo.

Citations

Apr 1, 1981·Thorax·I S PetheramS G Spiro
Jan 1, 1983·European Journal of Clinical Pharmacology·J W PatersonR A Tarala
Apr 1, 1981·Archives of Disease in Childhood·J K Sarsfield
Mar 12, 1983·British Medical Journal·D C Flenley
Dec 8, 2011·Journal of Immunotoxicology·Savita D PatilSanjay J Surana
Sep 1, 1985·Clinical Allergy·B G LoftusJ F Costello
Nov 1, 1983·Thorax·J R CatterallD C Flenley
Sep 1, 1981·British Journal of Clinical Pharmacology·M I UllahK B Saunders
Dec 18, 2012·Gut·Sjoerd H W van BreeGianluca Matteoli
Oct 1, 1982·Clinical Allergy·J O Warner, S J Goldsworthy

Related Concepts

Adrenal Cortex Hormones
Sultanol
Asthma
Clinical Trials
Double-Blind Method
Polychemotherapy
Antihistamines, Classical
Ketotifen Fumarate
Piperidines
Sleep Stages

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