PMID: 8473680Apr 1, 1993Paper

Ketotifen inhibits exacerbation of allergic airway hyperreactivity by racemic salbutamol in the guinea pig

The Journal of Allergy and Clinical Immunology
K HoshikoJ Morley

Abstract

In passively sensitized anesthetized guinea pigs, intravenous infusion of low doses of antigen ovalbumin induced a marked increased responsivity of the airways to intravenous injection of leukotriene C4. Sustained infusion of racemic salbutamol intensified responses to leukotriene C4 both before and after infusion of ovalbumin. Hyperreactivity as a result of infusion of ovalbumin was inhibited by intraduodenal injection of either hydrocortisone or ketotifen at doses that did not diminish responses to leukotriene C4 in animals not exposed to antigen. Ketotifen, but not hydrocortisone, inhibited the enhanced hyperreactivity associated with infusion of racemic salbutamol.

References

Jan 1, 1989·Agents and Actions·J Morley, D Smith
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Jan 1, 1984·Respiration; International Review of Thoracic Diseases·G H KoëterK de Vries

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Citations

May 1, 1996·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·L KahhakJ Benveniste
Jan 1, 1996·Clinical Reviews in Allergy & Immunology·R P BakaleC M Zepp
Jan 1, 1996·Clinical Reviews in Allergy & Immunology·J Morley
Jan 1, 1996·Clinical Reviews in Allergy & Immunology·A JafarianD F Biggs
Jan 1, 1996·Clinical Reviews in Allergy & Immunology·M Perrin-FayolleM T Chambe
Jul 16, 1994·Lancet·J Morley
Jul 20, 2005·Pediatric Emergency Care·Madhu D HardasmalaniNina Gold
Jun 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S D CrowtherJ Morley
Feb 1, 2006·International Archives of Allergy and Immunology·Basil O IbeJ Usha Raj
Jul 7, 2000·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·D A HandleyJ Caron
Sep 30, 2005·Pediatric Pulmonology·David P SkonerRudolf A Baumgartner
Aug 8, 2006·Pulmonary Pharmacology & Therapeutics·Gary MaierRudolf A Baumgartner
Jan 1, 1995·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·P RadielovicT C Medici
Dec 14, 2001·The Journal of Allergy and Clinical Immunology·H MilgromUNKNOWN Levalbuterol Pediatric Study Group

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