PMID: 7539727Jun 1, 1995Paper

Ketotifen therapy in chronic graft-versus-host disease (cGVHD): effect on mast cells and fibroblasts

Clinical and Experimental Immunology
A NaglerF Levi-Schaffer

Abstract

Current treatment options for cGVHD are limited. Mast cells (MC) and fibroblasts have been shown to play a role in the murine model of cGVHD. Ketotifen is an anti-H-1 antihistamine with MC-stabilizing properties. We therefore treated eight patients with cGVHD with ketotifen (6 micrograms/day for 3 months). Three additional age- and sex-matched cGVHD patients served as controls. MC count and activation state in cGVHD skin biopsies and the in vitro effect of peripheral blood mononuclear cell (PBMC) supernatants on (i) histamine release by MC; (ii) 3T3-fibroblast proliferation; and (iii) prostaglandin E2 (PGE2) production, were evaluated. Ketotifen therapy resulted in clinical improvement in 4/8 patients, stabilization of the disease in 2/8, while in 2/8 patients the cGVHD progressed and they died of bacterial sepsis. Side effects were minimal. In the skin biopsies the number of MC was found to be 0.58 +/- 0.17 (n = 8) (field x 400) and the MC looked degranulated (toluidine blue staining). Following ketotifen therapy MC number was increased to 1.2 +/- 0.28 (n = 8) (P < 0.05). PBMC supernatants of cGVHD patients stimulated histamine release from cultured rat MC (n = 8) (2.7 +/- 0.5 micrograms/ml; normal values are 2.1 +/- 0.4 micro...Continue Reading

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Citations

May 1, 1997·The Australasian Journal of Dermatology·M L AndrewsD Weedon
May 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·F Levi-Schaffer, V B Weg
Jan 25, 2005·American Journal of Clinical Dermatology·Pablo F PeñasAmaro García-Diez
Oct 11, 2014·The Australasian Journal of Dermatology·Kieran B Garbutcheon-Singh, Pablo Fernández-Peñas
Jul 17, 2001·Journal of Hematotherapy & Stem Cell Research·A NaglerY Ilan
Mar 31, 1998·Journal of the American Academy of Dermatology·M L Johnson, E R Farmer

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