Key compound groups for the neuroprotective effect of roots of Polygonum cuspidatum on transient middle cerebral artery occlusion in Sprague-Dawley rats

Natural Product Research
Jinmo KimYoungmin Bu

Abstract

Polygonum cuspidatum is a potent anti-oxidant herb that is well known for its various bioactivities. The current study investigates which compound group is most effective, to establish the key compound groups for quality assessment, especially in terms of neuroprotective effects. The roots of P. cuspidatum were extracted with 85% methanol and fractionated with hexane, ethyl acetate, n-butanol and water. Each fraction was applied to an in vitro radical scavenging assay, a lipid peroxidation assay in brain homogenates and an in vivo assay using a transient focal cerebra ischemia model induced by a middle cerebral artery occlusion in a Sprague-Dawley rat. The ethyl acetate fraction was the most effective fraction in both in vitro and in vivo assays, having the highest stilbene and anthraquinone contents. These results suggest that stilbenes and anthraquinones may be key compound groups for the quality assessment of the anti-oxidative and neuroprotective effects of P. cuspidatum.

References

Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Jan 1, 1981·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·A TamuraG M Teasdale
Jun 1, 1996·Stroke; a Journal of Cerebral Circulation·P H Chan
Oct 12, 2000·Journal of Ethnopharmacology·L D KongR X Tan
Apr 23, 2005·Neurological Research·Hocheol Kim
May 25, 2007·Pharmacology, Biochemistry, and Behavior·Aysan Durukan, Turgut Tatlisumak
Jul 13, 2007·Phytochemical Analysis : PCA·Tao YiZongwei Cai
Jul 28, 2007·Biological Research·Chin-Yuan HsuJeli Chang
Sep 28, 2007·European Journal of Pharmacology·Chaoyun WangJuntian Liu
Dec 11, 2007·Planta medica·Wu-Yang HuangMei Sun

❮ Previous
Next ❯

Citations

Jun 30, 2011·Immunopharmacology and Immunotoxicology·Jong-Hyun HanSung-Hoon Kim

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA

Software Mentioned

Optimas

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.