Key emerging issues in frontotemporal dementia

Journal of Neurology
Sarah A A Hopkins, Dennis Chan

Abstract

Frontotemporal dementia (FTD) encompasses the syndromes of behavioural variant FTD (bvFTD) and primary progressive aphasia (PPA) and refers to those neurodegenerative diseases characterised by predominant pathological involvement of the frontal and temporal lobes. Recent years have witnessed major advances in the clinical characterisation of FTD, reflected in the publication of updated diagnostic criteria for bvFTD and PPA, and the discovery of new pathogenic mutations has added to the understanding of genotype-phenotype interactions and of disease mechanisms. Emerging results from longitudinal studies of familial FTD show that imaging and cognitive changes occur years before symptom onset and such studies may yield biomarkers of early disease that in turn will facilitate earlier diagnosis. The hope and (guarded) expectation is that these advances may together herald the beginning of the end of the chapter in which FTD is considered an inexorably progressive and untreatable condition.

References

Jun 1, 1997·Brain : a Journal of Neurology·T Edwards-LeeI Mena
Oct 9, 2002·Neurology·Catherine Lomen-HoerthBruce Miller
Aug 24, 2005·Neurology·G M RingholzP E Schulz
Feb 24, 2006·Brain : a Journal of Neurology·Caroline VanceChristopher E Shaw
Mar 20, 2009·Brain : a Journal of Neurology·Dennis ChanNick C Fox
Apr 21, 2009·Neuron·William W SeeleyMichael D Greicius
Jan 18, 2011·Journal of Alzheimer's Disease : JAD·Catherine PenningtonMichael Hornberger
Feb 18, 2011·Neurology·M L Gorno-TempiniM Grossman
May 27, 2011·Acta Neuropathologica·Keith A JosephsDennis W Dickson
Aug 4, 2011·Brain : a Journal of Neurology·Katya RascovskyBruce L Miller
Sep 1, 2011·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Nathan HerrmannKrista L Lanctôt
Mar 9, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Baber K KhanBruce L Miller
May 11, 2012·Neurology·S A SajjadiP J Nestor
Nov 1, 2012·Human Mutation·Julie van der ZeeUNKNOWN European Early-Onset Dementia Consortium
Nov 21, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Massimo FilippiAndrea Falini
Aug 8, 2013·BMJ : British Medical Journal·Jason D WarrenMartin N Rossor
Oct 22, 2013·Neurology·Jennifer M HarrisMatthew Jones
Jan 15, 2014·Journal of Neurology, Neurosurgery, and Psychiatry·Leone ChareGlenda M Halliday
Jan 21, 2014·Acta Neuropathologica·Michael D GallagherAlice S Chen-Plotkin
Mar 7, 2014·Neuropsychiatric Disease and Treatment·Lina RiedlJanine Diehl-Schmid
Jul 23, 2014·Human Brain Mapping·Bonnie Y K LamOlivier Piguet
Nov 5, 2014·Annals of Neurology·Colin J MahoneyNick C Fox
Feb 14, 2015·Cell·Rita GuerreiroJohn Hardy
Mar 26, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael EwersHarald Hampel
Apr 29, 2015·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Sicong TuMichael Hornberger
Jul 5, 2015·Brain : a Journal of Neurology·Rik OssenkoppeleGil D Rabinovici

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Citations

Nov 19, 2015·Frontiers in Aging Neuroscience·Illana Gozes, Yanina Ivashko-Pachima

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