Key Features of the Intragraft Microenvironment that Determine Long-Term Survival Following Transplantation.

Frontiers in Immunology
Sarah BruneauD M Briscoe

Abstract

In this review, we discuss how changes in the intragraft microenvironment serve to promote or sustain the development of chronic allograft rejection. We propose two key elements within the microenvironment that contribute to the rejection process. The first is endothelial cell proliferation and angiogenesis that serve to create abnormal microvascular blood flow patterns as well as local tissue hypoxia, and precedes endothelial-to-mesenchymal transition. The second is the overexpression of local cytokines and growth factors that serve to sustain inflammation and, in turn, function to promote a leukocyte-induced angiogenesis reaction. Central to both events is overexpression of vascular endothelial growth factor (VEGF), which is both pro-inflammatory and pro-angiogenic, and thus drives progression of the chronic rejection microenvironment. In our discussion, we focus on how inflammation results in angiogenesis and how leukocyte-induced angiogenesis is pathological. We also discuss how VEGF is a master control factor that fosters the development of the chronic rejection microenvironment. Overall, this review provides insight into the intragraft microenvironment as an important paradigm for future direction in the field.

Citations

Jun 2, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xinguo JiangMark R Nicolls
Aug 12, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R C StarlingUNKNOWN CTOT-05 consortium
Dec 25, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Kevin P DalyDavid M Briscoe
Mar 2, 2016·American Journal of Respiratory and Critical Care Medicine·Mark R NicollsNiccolò Daddi
Jan 8, 2015·Current Opinion in Organ Transplantation·Johannes WedelDavid M Briscoe
Jun 14, 2018·Physiological Reviews·Alexandre CaronMathieu Laplante
Mar 28, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Michael E SeifertRoslyn B Mannon
May 7, 2015·Current Opinion in Organ Transplantation·Anthony J DemetrisJacqueline G O'Leary
May 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicole M ValenzuelaElaine F Reed
Mar 14, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Yi-Chun Xu-DuboisEric Rondeau
Apr 24, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sarah BruneauDavid M Briscoe
Feb 25, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi-Ping JinElaine F Reed
Jul 15, 2017·Transplantation Direct·Roel BijkerkMarlies E J Reinders
Aug 9, 2020·International Journal of Molecular Sciences·Koen E GroenewegRoel Bijkerk
Apr 1, 2020·International Wound Journal·Dominic HennGeoffrey C Gurtner
Nov 30, 2016·Current Opinion in Organ Transplantation·Johannes WedelDavid M Briscoe

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BETA
intragraft

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