Key genes involved in the immune response are generally not associated with intraprostatic inflammation in men without a prostate cancer diagnosis: Results from the prostate cancer prevention trial

The Prostate
Danyelle A WinchesterElizabeth A Platz

Abstract

We previously reported that both intraprostatic inflammation and SNPs in genes involved in the immune response are associated with prostate cancer risk and disease grade. In the present study, we evaluated the association between these SNPs and intraprostatic inflammation in men without a prostate cancer diagnosis. Included in this cross-sectional study were 205 white controls from a case-control study nested in the placebo arm of the Prostate Cancer Prevention Trial. We analyzed inflammation data from the review of H&E-stained prostate tissue sections from biopsies performed per protocol at the end of the trial irrespective of clinical indication, and data for 16 SNPs in key genes involved in the immune response (IL1β, IL2, IL4, IL6, IL8, IL10, IL12(p40), IFNG, MSR1, RNASEL, TLR4, TNFA; 7 tagSNPs in IL10). Logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (CI) for the association between carrying at least one minor allele and having at least one biopsy core (of a mean of three reviewed) with inflammation. None of the SNPs evaluated was statistically significantly associated with having at least one core with inflammation. However, possible inverse associations were present for carrying the ...Continue Reading

References

Feb 1, 1997·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·D M TurnerI V Hutchinson
Jun 26, 2003·The New England Journal of Medicine·Ian M ThompsonCharles A Coltman
Sep 3, 2004·Nature Reviews. Immunology·Thomas R Malek, Allison L Bayer
Oct 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Huihua Li, Bee Choo Tai
Mar 27, 2007·Nature Reviews. Cancer·Angelo M De MarzoWilliam G Nelson
Jun 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karen Sandell SfanosCharles G Drake
Jun 21, 2008·Nature Reviews. Immunology·Dario A A VignaliCreg J Workman
Mar 26, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kathleen EbeltElfriede Noessner
May 26, 2009·Immunity·Liang ZhouDan R Littman
Jun 26, 2010·Carcinogenesis·Mara S MeyerLorelei A Mucci
Dec 15, 2010·Cancer Prevention Research·Phyllis J GoodmanScott M Lippman
Dec 17, 2010·Science Translational Medicine·Julius GudmundssonKari Stefansson
Apr 22, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Bora GurelElizabeth A Platz

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