Key issues in handling and reporting radical prostatectomy specimens.

Archives of Pathology & Laboratory Medicine
John R Srigley

Abstract

Patients with prostatic adenocarcinoma commonly undergo radical prostatectomy, and it is often difficult and time consuming to handle the resulting specimens and to report the findings. Pathologic information derived from the radical prostatectomy specimen is used for selecting adjuvant therapy, such as radiotherapy and hormone therapy, and for determining a patient's prognosis. The prostate specimen must be handled in a systematic fashion to derive the appropriate prognostic parameters. To review the prognostic factors of relevance in classifying radical prostatectomy specimens, using the College of American Pathologists categorization system, including a detailed survey of the morphologic-based factors but excluding other factors such as DNA ploidy and novel phenotypic and genotypic markers. Gleason score, pathologic stage, and margin status are considered category 1 prognostic factors, which are of proven prognostic significance and are useful in patient management. Factors such as tumor volume (intraglandular extent) and tumor subtype are considered category 2 prognostic factors, which show significant promise but require validation in multivariate analysis. Lymphovascular space invasion is a promising category 3 prognostic...Continue Reading

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Citations

Feb 19, 2010·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Joseph L ChinAndrew Evans
Oct 2, 2009·Archives of Pathology & Laboratory Medicine·John R SrigleyUNKNOWN Members of the Cancer Committee, College of American Pathologists
Dec 8, 2006·Archives of Pathology & Laboratory Medicine·Kiril Trpkov, Larry Warman
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Sep 8, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Daniel M BerneyUNKNOWN ISUP Prostate Cancer Group
Sep 14, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Hemamali SamaratungaUNKNOWN ISUP Prostate Cancer Group
Feb 18, 2011·Histopathology·Ben VainerNiels Marcussen

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