Key-properties outlook of a levofloxacin-loaded acrylic bone cement with improved antibiotic delivery

International Journal of Pharmaceutics
Ana C MatosAna F Bettencourt

Abstract

Antibiotic-loaded acrylic bone cements (ALABCs) are widely used to decrease the occurrence of bone infections in cemented arthroplasties and actually being considered as a more cost-effective procedure when compared to cementless implants. However, ALABCs have a major drawback, which is the incomplete release of the antibiotics and, as a result, pathogens that commonly are responsible for those infections are becoming resistant. Consequently, it is of most relevance to find new antibacterial agents to load into BC with an effective mechanism against those microorganisms. This research work intended to load levofloxacin, a fluoroquinolone with anti-staphylococcal activity and adequate penetration into osteoarticular tissues, on lactose-modified commercial bone cement (BC). This modified BC matrix exhibited increased levofloxacin release and delayed Staphylococcus aureus biofilm formation. Further insights on material-drug interaction during BC setting were investigated by density functional theory calculations. The obtained results suggested that favorable covalent and non-covalent interactions could be established between levofloxacin and the BC. Moreover, BC mechanical and biocompatibility properties were maintained. These fea...Continue Reading

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Citations

May 24, 2015·International Journal of Pharmaceutics·Ana C MatosAna F Bettencourt
Jun 10, 2020·Drug Delivery and Translational Research·Magda FerreiraMaria Manuela Gaspar
Sep 1, 2021·Colloids and Surfaces. B, Biointerfaces·Rita M MendesIsabel A C Ribeiro

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