Key role of postchallenge hyperglycemia for the presence and extent of coronary atherosclerosis: an angiographic study

Atherosclerosis
Christoph H SaelyThomas C Wascher

Abstract

The associations between impaired glucose tolerance (IGT) and postchallenge diabetes with the presence and extent of angiographically characterized coronary atherosclerosis are unclear. We enrolled 1040 consecutive Caucasian patients undergoing coronary angiography for the evaluation of coronary artery disease (CAD). An oral 75-g glucose tolerance test was performed in patients without previously diagnosed diabetes. From our patients, 394 had normal glucose tolerance (NGT), 190 impaired glucose tolerance (IGT), 90 isolated postchallenge diabetes (postchallenge glucose >or=200 mg/dl), and 366 type 2 diabetes previously established or newly diagnosed on the basis of fasting glucose (conventional diabetes). Coronary atherosclerosis was more frequent in patients with IGT, isolated postchallenge diabetes, or conventional diabetes when compared to NGT subjects (87.9, 95.6, 89.1 versus 80.7%; p=0.030, 0.001, 0.043, respectively). The prevalence of significant coronary stenoses >or=50%, compared to NGT subjects (57.4%), was similar in IGT patients (59.5%; p=0.628), but significantly higher in patients with isolated postchallenge diabetes (77.8%; p=0.001) or conventional diabetes (68.0%; p=0.002). Also the number of significant stenoses...Continue Reading

References

May 11, 1979·JAMA : the Journal of the American Medical Association·W B Kannel, D L McGee
Feb 1, 1983·The American Journal of Cardiology·G G Gensini
Jan 1, 1995·Annual Review of Medicine·M Brownlee
Apr 22, 2004·JAMA : the Journal of the American Medical Association·Ferdinando C SassoDomenico Cozzolino
Apr 7, 2006·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·M LankischStephan Martin

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Citations

Nov 26, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S BeerH Drexel
Mar 17, 2010·Wiener medizinische Wochenschrift·Michael Resl, Martin Clodi
Jan 31, 2009·PloS One·José Pedro L Nunes, João Carlos Silva
Nov 18, 2008·Diabetes Research and Clinical Practice·Mehdi RambodFereidoun Azizi
Aug 29, 2013·European Journal of Clinical Investigation·Natalia ColomoFederico Soriguer
Aug 10, 2011·The American Journal of Cardiology·Ralph A DeFronzo, Muhammad Abdul-Ghani
Apr 8, 2016·Wiener klinische Wochenschrift·Martin ClodiBernd Eber
Dec 28, 2010·Diabetes Research and Clinical Practice·Zhu-Zhi WenDeng-Feng Geng
Apr 10, 2012·International Journal of Cardiology·Christoph H SaelyHeinz Drexel
Jan 27, 2015·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Guenther SilbernagelHeinz Drexel
Sep 7, 2018·Current Opinion in Cardiology·Sonya K HuiMarc Ruel
Feb 1, 2020·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Lifei CaoGang Tian
Aug 6, 2014·Angiology·Azan Salim BinbrekAlawi Al Sheikh Ali
Apr 14, 2019·Wiener klinische Wochenschrift·Martin ClodiHarald Sourij
Dec 1, 2018·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Sonya Kit HuiMarc Ruel
Nov 17, 2020·Frontiers in Cardiovascular Medicine·Nordin M J HanssenAndrew J Murphy

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