Key role of the GITR/GITRLigand pathway in the development of murine autoimmune diabetes: a potential therapeutic target.

PloS One
Sylvaine YouLucienne Chatenoud

Abstract

The cross-talk between pathogenic T lymphocytes and regulatory T cells (Tregs) plays a major role in the progression of autoimmune diseases. Our objective is to identify molecules and/or pathways involved in this interaction and representing potential targets for innovative therapies. Glucocorticoid-induced tumor necrosis factor receptor (GITR) and its ligand are key players in the T effector/Treg interaction. GITR is expressed at low levels on resting T cells and is significantly up-regulated upon activation. Constitutive high expression of GITR is detected only on Tregs. GITR interacts with its ligand mainly expressed on antigen presenting cells and endothelial cells. It has been suggested that GITR triggering activates effector T lymphocytes while inhibiting Tregs thus contributing to the amplification of immune responses. In this study, we examined the role of GITR/GITRLigand interaction in the progression of autoimmune diabetes. Treatment of 10-day-old non-obese diabetic (NOD) mice, which spontaneously develop diabetes, with an agonistic GITR-specific antibody induced a significant acceleration of disease onset (80% at 12 weeks of age). This activity was not due to a decline in the numbers or functional capacity of CD4(+)C...Continue Reading

References

May 1, 1992·International Journal of Cell Cloning·F LepaultJ F Bach
Jan 1, 1980·Jikken dobutsu. Experimental animals·S MakinoY Tochino
Aug 1, 1994·Endocrine Reviews·J F Bach
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·F Lepault, M C Gagnerault
Feb 26, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·H HiraiK Kida
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A BotM von Herrath
May 31, 2002·The New England Journal of Medicine·UNKNOWN Diabetes Prevention Trial--Type 1 Diabetes Study Group
May 31, 2002·The New England Journal of Medicine·Kevan C HeroldJeffrey A Bluestone
Jun 19, 2002·Blood·Simona RonchettiPier Paolo Pandolfi
Sep 20, 2002·The New England Journal of Medicine·Jean-Francois Bach
Oct 4, 2002·The New England Journal of Medicine·Joep Killestein
Mar 27, 2003·Nature Reviews. Immunology·Jeffrey A Bluestone, Abul K Abbas
Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sylvaine YouChih-Pin Liu
May 20, 2003·Journal of Autoimmunity·Darcy B Wilson
Nov 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Masahide ToneHerman Waldmann
Nov 18, 2003·Immunological Reviews·Stephen P CobboldHerman Waldmann
Dec 4, 2003·Genes and Immunity·J D KimB S Kwon
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Marie-Alexandra AlyanakianJean-François Bach
Mar 3, 2004·European Journal of Immunology·Simona RonchettiCarlo Riccardi
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adam P KohmStephen D Miller
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hong-bin JiCox Terhorst
May 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephen P CobboldHerman Waldmann
Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fumiko KanamaruMiyuki Azuma
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Geoffrey L StephensEthan M Shevach
Jun 24, 2005·The New England Journal of Medicine·Bart KeymeulenLucienne Chatenoud
Jul 30, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Salvatore CuzzocreaCarlo Riccardi
Sep 17, 2005·The Journal of Clinical Investigation·Brygida BisikirskaKevan C Herold

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Citations

Nov 30, 2013·Chemico-biological Interactions·Jingfeng OuyangYongping Yu
Oct 11, 2011·Therapeutic Delivery·Chuda ChittasuphoCory Berkland
Feb 4, 2014·Cytokine & Growth Factor Reviews·Derek L Clouthier, Tania H Watts
May 19, 2010·Cancer Immunology, Immunotherapy : CII·David CoeJian-Guo Chai
Oct 29, 2010·Expert Review of Clinical Immunology·Rodolfo José Chaparro, Teresa P Dilorenzo
Dec 16, 2011·Trends in Immunology·Michael CroftAmit Mehta
Oct 5, 2010·Immunology Letters·Simona RonchettiCarlo Riccardi
Oct 25, 2011·Immunological Reviews·Laura M SnellTania H Watts
Oct 28, 2011·British Journal of Pharmacology·Giuseppe NocentiniCarlo Riccardi
Aug 15, 2018·Expert Opinion on Therapeutic Targets·Carlo RiccardiGiuseppe Nocentini
Feb 15, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jie TianShengjun Wang
Jun 28, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nienke van der WerfMatthew D Taylor
Jul 3, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gillian KinnearNick D Jones
Nov 7, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anabelle Visperas, Dario A A Vignali

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Methods Mentioned

BETA
transgenic
flow cytometry
FACS

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