Key stages in mammary gland development: the cues that regulate ductal branching morphogenesis

Breast Cancer Research : BCR
Mark D Sternlicht

Abstract

Part of how the mammary gland fulfills its function of producing and delivering adequate amounts of milk is by forming an extensive tree-like network of branched ducts from a rudimentary epithelial bud. This process, termed branching morphogenesis, begins in fetal development, pauses after birth, resumes in response to estrogens at puberty, and is refined in response to cyclic ovarian stimulation once the margins of the mammary fat pad are met. Thus it is driven by systemic hormonal stimuli that elicit local paracrine interactions between the developing epithelial ducts and their adjacent embryonic mesenchyme or postnatal stroma. This local cellular cross-talk, in turn, orchestrates the tissue remodeling that ultimately produces a mature ductal tree. Although the precise mechanisms are still unclear, our understanding of branching in the mammary gland and elsewhere is rapidly improving. Moreover, many of these mechanisms are hijacked, bypassed, or corrupted during the development and progression of cancer. Thus a clearer understanding of the underlying endocrine and paracrine pathways that regulate mammary branching may shed light on how they contribute to cancer and how their ill effects might be overcome or entirely avoided.

References

Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·C BriskenR A Weinberg
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·C R FisherE R Simpson
Oct 20, 1999·Developmental Biology·T C KlinowskaC H Streuli
May 3, 2000·Journal of Mammary Gland Biology and Neoplasia·D L KleinbergW Ruan
Oct 1, 1996·Journal of Mammary Gland Biology and Neoplasia·C W DanielG B Silberstein
Aug 5, 2000·Endocrinology·W P BocchinfusoK S Korach
Jan 10, 2001·Journal of Mammary Gland Biology and Neoplasia·B A Howard, B A Gusterson
Jul 27, 2001·Journal of Mammary Gland Biology and Neoplasia·M T Lewis
Sep 5, 2001·Nature Cell Biology·S K RunswickD R Garrod
Nov 1, 2001·Annual Review of Cell and Developmental Biology·M D Sternlicht, Z Werb
Jul 3, 2002·Nature Reviews. Molecular Cell Biology·Lucy Erin O'BrienKeith E Mostov
Jul 9, 2002·Breast Cancer Research : BCR·Valérie Gouon-EvansJeffrey W Pollard
Aug 31, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Matthew J Naylor, Christopher J Ormandy
Jan 16, 2003·Cell·Barry Lubarsky, Mark A Krasnow
Jan 18, 2003·Developmental Cell·Markus AffolterZena Werb
Jun 20, 2003·Nature·Takayoshi SakaiKenneth M Yamada
Jun 26, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hester TidcombeJon P Golding
Jul 31, 2003·Trends in Cell Biology·Derek C RadiskyMina J Bissell
Nov 26, 2003·Journal of Mammary Gland Biology and Neoplasia·Orla M ConneelyJohn P Lydon
Dec 19, 2003·Breast Cancer Research : BCR·Jimmie E FataMina J Bissell
Dec 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Amy J Jackson-FisherDavid F Stern
Jun 21, 2005·Current Opinion in Genetics & Development·Jamie A Davies
Nov 11, 2005·Breast Cancer Research : BCR·Lindsay Hinck, Gary B Silberstein
Jul 12, 2007·Journal of Mammary Gland Biology and Neoplasia·Sarah Hatsell, Andra R Frost

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Citations

Nov 15, 2008·Histochemistry and Cell Biology·Cyrus M Ghajar, Mina J Bissell
Sep 14, 2011·Histochemistry and Cell Biology·Ken Kobayashi, Haruto Kumura
Jan 18, 2013·Functional & Integrative Genomics·Mini SinghHerman W Raadsma
Apr 12, 2008·Breast Cancer Research and Treatment·Charles E WoodJ Mark Cline
Nov 23, 2006·Journal of Mammary Gland Biology and Neoplasia·Pengfei LuZena Werb
Nov 18, 2006·Journal of Mammary Gland Biology and Neoplasia·Marja L Mikkola, Sarah E Millar
Nov 23, 2006·Journal of Mammary Gland Biology and Neoplasia·Mauricio J Reginato, Senthil K Muthuswamy
Feb 7, 2008·Journal of Mammary Gland Biology and Neoplasia·Jo K PerryPeter E Lobie
May 6, 2008·Journal of Mammary Gland Biology and Neoplasia·David F Stern
May 13, 2008·Journal of Mammary Gland Biology and Neoplasia·Mark D Sternlicht, Susan W Sunnarborg
May 11, 2012·Journal of Mammary Gland Biology and Neoplasia·Alvin T LoMina J Bissell
May 28, 2009·Medical Oncology·Majid MojarradMohammad Hussein Modarressi
Mar 1, 2008·Animal : an International Journal of Animal Bioscience·G JolivetL M Houdebine
Apr 26, 2012·Chemical Research in Toxicology·Slobodan Rendic, F Peter Guengerich
Jan 1, 2010·Cell Death & Disease·B L Allen-PetersenM E Reyland
Aug 11, 2011·Nature Reviews. Molecular Cell Biology·Nikolce Gjorevski, Celeste M Nelson
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Pingping JiangXiaoting Zhang
Dec 6, 2012·The Journal of Biological Chemistry·Kaitlin J BashamBryan E Welm
Oct 13, 2012·The Journal of Biological Chemistry·Kevin T BushSanjay K Nigam
May 15, 2012·Breastfeeding Medicine : the Official Journal of the Academy of Breastfeeding Medicine·Armond S Goldman
May 12, 2012·Stem Cells and Development·Jan H SpaasGerlinde R Van de Walle
Feb 2, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yong ZhaoChengfeng Yang
Apr 20, 2013·The American Journal of Dermatopathology·Margot S PetersNneka I Comfere
Aug 13, 2010·Cold Spring Harbor Perspectives in Biology·John Muschler, Charles H Streuli
Nov 26, 2010·Cold Spring Harbor Perspectives in Biology·Rama Khokha, Zena Werb
Nov 28, 2007·Annual Review of Pathology·Christy HebnerJayanta Debnath
Sep 17, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M R FooteY R Boisclair
Dec 1, 2011·Cancer Research·Cristina CelluraleRoger J Davis
Jan 25, 2008·BMC Developmental Biology·Harriet WatkinSteven M Anderson
Jul 13, 2006·Breast Cancer Research : BCR·Magnus D LynchAnand D Purushotham
Jul 31, 2007·Breast Cancer Research : BCR·Heather L LaMarca, Jeffrey M Rosen
Mar 29, 2008·Breast Cancer Research : BCR·Alastair ThompsonCharles Streuli
Oct 7, 2010·Breast Cancer Research : BCR·Ellen CohnEduardo F Farias
Aug 14, 2013·Breast Cancer Research : BCR·Charles E WoodWilliam C Dougall
Nov 2, 2012·Stem Cell Research & Therapy·Sriram Manivannan, Celeste M Nelson
Nov 26, 2010·Development·Alethia VillasenorOndine Cleaver
Mar 31, 2012·Development·Sarah J KurleyAlbert B Reynolds

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Methods Mentioned

BETA
transgenic

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