Kg, a new low-frequency red cell antigen responsible for hemolytic disease of the newborn

Vox Sanguinis
Y IchikawaA Lubenko

Abstract

Hemolytic disease of the newborn in a Japanese infant led to studies which indicate that an antibody detected in the maternal serum is recognizing a hitherto unknown red cell antigen. The antigen, which we have named Kg, was found in two generations of the family and it is inherited as a Mendelian dominant character. The maternal serum failed to react with the red cells of more than 600 random Japanese blood donors, 64 red cell samples known to possess low-frequency antigens and all but one of 75 red cell samples known to lack high-frequency antigens without recognized low-frequency antigens. The father's red cells were tested extensively for established low-frequency antigens; only Dia was demonstrated and the maternal antibody was shown not to contain anti-Dia.

References

Jan 1, 1963·Journal of Clinical Pathology·H RUBIN
Mar 1, 1965·Transfusion·M STROUP, M MACILROY

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Citations

Aug 14, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Satomi KuboHideki Minowa
May 11, 2000·Blood Reviews·J Poole
Jul 25, 2020·British Journal of Haematology·Mitsunobu TanakaYoshihiro Takihara
Oct 5, 2021·Transfusion·Mitsunobu TanakaYoshihiro Takihara

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