Khat chewing, cardiovascular diseases and other internal medical problems: the current situation and directions for future research

Journal of Ethnopharmacology
A Al-MotarrebK J Broadley

Abstract

The leaves of khat (Catha edulis Forsk.) are chewed as a social habit for the central stimulant action of their cathinone content. This review summarizes the prevalence of the habit worldwide, the actions, uses, constituents and adverse health effects of khat chewing. There is growing concern about the health hazards of chronic khat chewing and this review concentrates on the adverse effects on health in the peripheral systems of the body, including the cardiovascular system and gastrointestinal tract. Comparisons are made with amphetamine and ecstasy in particular on the detrimental effects on the cardiovascular system. The underlying mechanisms of action of khat and its main constituent, cathinone, on the cardiovascular system are discussed. Links have been proposed between khat chewing and the incidence of myocardial infarction, dilated cardiomyopathy, vascular disease such as hypertension, cerebrovascular ischaemia and thromboembolism, diabetes, sexual dysfunction, duodenal ulcer and hepatitis. The evidence, however, is often based on limited numbers of case reports and only few prospective controlled studies have been undertaken. There is therefore an urgent need for more thorough case-control studies to be performed. This...Continue Reading

References

Feb 1, 1992·Pharmacology & Toxicology·P Kalix
Dec 1, 1990·British Journal of Clinical Pharmacology·R BrenneisenP Kalix
Mar 16, 1990·Toxicology·M W IslamI Ashraf
Apr 1, 1986·The Journal of Pharmacy and Pharmacology·R BrenneisenX Schorno
May 1, 1982·The Journal of Pharmacy and Pharmacology·J D Kohli, L I Goldberg
Jan 1, 1984·General Pharmacology·P Kalix
Oct 1, 1982·Annals of Internal Medicine·T D CallA G Bartel
Jun 1, 1994·The Australian and New Zealand Journal of Psychiatry·A D Jager, L Sireling
Jan 1, 1994·Drug and Chemical Toxicology·M W IslamN M al-Gharably
Apr 1, 1996·Pharmacy World & Science : PWS·P Kalix
Dec 1, 1995·Journal of Ethnopharmacology·J M HalketI M Murray-Lyon
Dec 1, 1996·Journal of Autonomic Pharmacology·K J Broadley, H L Maddock
Sep 2, 1999·Acta Psychiatrica Scandinavica. Supplementum·A AlemG Kullgren
Sep 2, 2000·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·E Makonnen
Feb 16, 2002·Heart·A Al-MotarrebK J Broadley
Aug 31, 2002·Phytotherapy Research : PTR·Ahmed Al-MotarrebKenneth J Broadley
Nov 12, 2002·Journal of Ethnopharmacology·Molham Al-HaboriM Baker
Jan 1, 2003·Current Neurology and Neuroscience Reports·Askiel Bruno
May 10, 2003·Journal of Ethnopharmacology·N MuruganI M Murray-Lyon
Jul 17, 2004·Autonomic & Autacoid Pharmacology·A L Al-Motarreb, K J Broadley
Nov 4, 2004·British Journal of Clinical Pharmacology·A M Crean, J E F Pohl
Jan 8, 2005·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M Al-Habori, M Al-Mamary
Apr 22, 2005·British Journal of Clinical Pharmacology·A Al-MotarrebK J Broadley
Sep 20, 2005·The Australian and New Zealand Journal of Psychiatry·Johana Stefan, Babu Mathew
Oct 4, 2005·Journal of Ethnopharmacology·Jason M MwendaDaudi K Langat
Nov 1, 2005·Expert Opinion on Drug Safety·Molham Al-Habori
Apr 20, 2006·International Dental Journal·Saba Kassim, Ray Croucher
Jun 13, 2006·Cerebrovascular Diseases·Iris E VanwalleghemJan L De Bleecker
Jul 26, 2006·European Journal of Internal Medicine·J M BrostoffJ Birns
Sep 14, 2007·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Yedidia BenturBianca Raikhlin-Eisenkraft
Oct 10, 2007·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·S de RidderL Hofstra
Mar 21, 2008·Drug and Alcohol Dependence·Arthur N WestoverRobert W Haley
Sep 12, 2008·Regulatory Toxicology and Pharmacology : RTP·E J M PenningsJ G C van Amsterdam
Jan 10, 2009·British Dental Journal·Y A M El-Wajeh, M H Thornhill
May 22, 2009·Journal of Psychoactive Drugs·Rita Annoni ManghiDaniele Fabio Zullino
Apr 23, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·Camilla G PeeversC Anne McCune
Apr 30, 2010·The New England Journal of Medicine·Michael H ChapmanMarsha Y Morgan

❮ Previous
Next ❯

Citations

Nov 24, 2011·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Jane M Prosser, Lewis S Nelson
Sep 20, 2012·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Paul H YiRichard Saitz
Sep 20, 2012·Culture, Health & Sexuality·Della BerhanuTewabech Bishaw
Jan 1, 2014·Pediatric Emergency Care·Matthew D Thornton, Carl R Baum
Feb 2, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jassim Al SuwaidiSamir L Aleryani
Dec 10, 2013·Archives of Toxicology·Maria João ValenteMárcia Carvalho
Oct 2, 2015·Metabolic Brain Disease·S T KimaniP G Kioy
Sep 28, 2015·Journal of Analytical Toxicology·Wei-Yin HongHwei-Fang Cheng
May 21, 2011·Medicina clínica·Guillermo Burillo-PutzeSantiago Nogué Xarau
Jan 18, 2012·Addiction·Mustafa al'Absi, John Grabowski
Feb 19, 2013·The American Journal on Addictions·Mustafa al'AbsiLorentz Wittmers
Mar 31, 2016·Journal of Ethnopharmacology·Abdulsamad AlsalahiZahurin Mohamed
Aug 15, 2015·BioMed Research International·Saba KassimElie A Akl
Dec 22, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Abdulsamad AlsalahiMohammed A Alshawsh
Jun 13, 2015·Harm Reduction Journal·Saba KassimJosh Hulbert
Jan 17, 2012·Journal of Ethnopharmacology·Saba KassimRay Croucher
Jan 1, 2011·Case Reports in Critical Care·Marlene WewalkaChristian Zauner
May 15, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Patrick Dawson, James D Moffatt
Jul 30, 2014·Journal of Ethnopharmacology·Motohiro NakajimaMustafa al'Absi
Mar 31, 2015·Case Reports in Radiology·T J MeulmanE J van den Bos
May 12, 2016·Substance Abuse Treatment, Prevention, and Policy·Mowaffaq Awad SallamMaged El-Setouhy
Jun 2, 2016·BMC Complementary and Alternative Medicine·Tegegne BogaleEngida Yisma
May 31, 2017·Phytotherapy Research : PTR·Ephrem Engidawork
Nov 28, 2012·Journal of Pharmacy Practice·P Mas-MoreyD J Touw
Jan 26, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stian Magnus Staurung OrlienAsgeir Johannessen
Feb 15, 2018·BMC Gastroenterology·Stian Magnus Staurung OrlienAsgeir Johannessen
Feb 2, 2018·The Open Cardiovascular Medicine Journal·Teshale Ayele Mega, Nikodimos Eshetu Dabe
Aug 24, 2017·Journal of Investigative and Clinical Dentistry·Sadeq A Al-MaweriAbdulaziz Samran
Aug 30, 2012·Natural Product Reports·Warunya Arunotayanun, Simon Gibbons
Nov 16, 2019·Substance Use & Misuse·Mohammed AlshakkaMohamed Izham Mohamed Ibrahim
Nov 26, 2019·Substance Use & Misuse·Sagal AhmedAndrew Rasmussen
Sep 16, 2017·Journal of Food and Drug Analysis·Ling-Yi FengJih-Heng Li
Jun 1, 2018·Anemia·Abdullah Ahmed Al-AlimiMohammed Abdo Morish
Mar 14, 2020·Annals of General Psychiatry·Wondale Getinet AlemuShegaye Shumet Mekonnen
Jan 1, 2018·Advances in Pulmonary Hypertension·Ramon L RamirezRoham T Zamanian

❮ Previous
Next ❯

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