Khat use is associated with increased response conflict in humans

Human Psychopharmacology
Lorenza S ColzatoBernhard Hommel

Abstract

Khat consumption has become a worldwide phenomenon broadening from Eastern Africa and the south west of the Arabian Peninsula to ethnic communities in the rest of the world. Only few studies have systematically looked into cognitive impairments in khat users. We studied whether khat use is associated with changes in the emergence and resolution of response conflict, a central cognitive control function. Khat users (n = 16) and khat-free controls (n = 16) were matched in terms of sex, ethnicity, socio-economical situation, age, alcohol and cannabis consumption, and IQ (Raven's Progressive Matrices). Groups were tested on response conflict, as measured by the Simon task. Khat users performed significantly slower than controls and were more strongly affected by stimulus-induced response conflict. Khat use is associated with specific impairments in behavioral control: general slowing and less efficient resolution of response conflicts, which is likely to impair decision making in everyday life.

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Citations

Oct 1, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Motohiro NakajimaMustafa Al'Absi
Jun 15, 2013·European Journal of Pharmacology·Nicholas F Dybdal-HargreavesTyisha Williams
Jun 27, 2014·Substance Abuse : Official Publication of the Association for Medical Education and Research in Substance Abuse·Ahmed A IsmailMaged El-Setouhy
Aug 5, 2017·Substance Use & Misuse·Mowaffaq Awad SallamMaged El-Setouhy
Jan 11, 2018·The International Journal of Occupational and Environmental Medicine·Ahmed A IsmailIbrahim A Bani
Jun 9, 2021·Archives of Toxicology·Jorge SoaresJoão Paulo Capela
Jun 11, 2021·PloS One·Ayan AhmedDavinia M Resurrección

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