Ki-67 is an independent indicator in non-muscle invasive bladder cancer (NMIBC); combination of EORTC risk scores and Ki-67 expression could improve the risk stratification of NMIBC

Urologic Oncology
Weihong DingDing Qiang

Abstract

To prove the predicting role of Ki-67 expression and to demonstrate that the combination of European Organization for Research and Treatment of Cancer (EORTC) risk scores and Ki-67 staining status could improve the risk stratification in a large series of patients with non-muscle invasive bladder cancer (NMIBC). From October 2002 to July 2010, in our cohort, 332 patients who were treated with transurethral resection of the bladder tumor were diagnosed with NMIBC by histopathologic analysis. Two experienced uropathologists rereviewed the slides. The EORTC risk scores for recurrence and progression were determined. Ki-67 expression was evaluated using immunohistochemical studies and scored for intensity and area of staining. We correlated Ki-67 expression scores with clinical and pathologic variables. We evaluated the prognosis role of EORTC risk scores, Ki-67 staining, and their combination on tumor recurrence-free survival and progression-free survival (PFS) by univariate analysis, multivariate analysis, and Kaplan-Meier survival curves. With a median follow-up of 47 (range, 2-124) months, 119 patients (35.8%) had tumor recurrence and 40 patients (12%) had tumor progression. Ki-67 positivity (Ki-67>25%) was reported in 108 tumo...Continue Reading

References

Feb 1, 2000·Journal of Cellular Physiology·T Scholzen, J Gerdes
Dec 4, 2002·BJU International·R T Bryan, D M A Wallace
May 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bas W G van RhijnEllen C Zwarthoff
Oct 1, 2003·Urological Research·Bartosz DybowskiAndrzej Borkowski
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Aug 8, 2007·European Urology·Mark S Soloway
Apr 5, 2011·European Urology·Marko BabjukUNKNOWN European Association of Urology (EAU)

❮ Previous
Next ❯

Citations

May 9, 2018·Expert Review of Anticancer Therapy·David D'AndreaShahrokh F Shariat
Aug 19, 2015·Korean journal of urology·M Hammad Ather, Syed M Nazim
Mar 6, 2019·Current Oncology Reports·Aniruddha GangulyEdward Chu
Mar 11, 2018·Pathology Oncology Research : POR·Jéssica Niederauer Leote da SilvaClaudia Giuliano Bica
Dec 29, 2019·Journal of Cellular and Molecular Medicine·Yaoyi XiongXinghuan Wang
Sep 26, 2019·Journal of Histotechnology·Nahla Abdelfattah KamelShery Abdullah Ibrahim
Mar 16, 2016·Current Opinion in Oncology·Kristen R ScarpatoPeter E Clark
Apr 3, 2020·Journal of Cancer Research and Clinical Oncology·Aleksandra Semeniuk-WojtaśRafał Stec
Jan 28, 2021·OncoTargets and Therapy·Jiacheng WuXiaolin Wang
Aug 27, 2021·Annals of Diagnostic Pathology·Nouha Setti BoubakerSlah Ouerhani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.