Ki-67 is an indicator of progression of neuroendocrine tumors

Endocrine Pathology
Noriko KimuraHiroshi Nagura

Abstract

No current histological or cytological indices can distinguish reliably malignant from benign tumors in neuroendocrine tumors, including pheochromocytomas, pancreatic endocrine tumors, and carcinoid tumors. We investigated immunohistochemically the expression of Ki-67 in 52 neuroendocrine tumors, including 17 pheochromocytomas, 9 pancreatic endocrine tumors, 23 carcinoid tumors, 2 neuroendocrine carcinomas (NEC), and 1 neuroblastoma with liver metastasis. Of the 52 tumors, distant metastasis was observed in 4 pheochromocytomas, 2 pancreatic endocrine tumors, 4 carcinoids, 2 NEC, and 1 neuroblastoma. We classified these tumors into 3 groups; Groups A, B, and C, depending on the number of Ki-67-positive cells counted under a 200 x magnified field. Expression of Ki-67 was extremely high in group A (> 50 labeled nuclei/field), moderately high in group B (20-50 labeled nuclei), and very low in group C (< 10 labeled nuclei). There was a significant correlation between expression of Ki-67 and tumor progression. The tumors in group A progressed rapidly with the worst outcome; the tumors in group B progressed slowly but with a bad outcome; and the tumors in group C had no metastasis and a good prognosis. Ki-67 is an excellent indicator ...Continue Reading

References

Mar 1, 1988·The Journal of Pathology·P A HallA G Stansfeld
Jun 1, 1989·British Journal of Cancer·N BouzubarR I Nicholson
Jun 1, 1985·Human Pathology·L J MedeirosM Federman
Sep 1, 1994·Endocrine Pathology·Noriko KimuraHiroshi Nagura

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Citations

Jun 22, 2000·The Journal of Pathology·E van der HarstR R de Krijger
Jun 30, 2019·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Tomoo KudoKinji Shirota
Mar 20, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Irfan OcalHuseyin Can

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