Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies

Human Pathology
I M Shih, R J Kurman

Abstract

The diagnosis of placental site trophoblastic lesions, particularly the distinction of a placental site trophoblastic tumor from an exaggerated placental site, can be difficult. Mel-CAM (also known as CD146 and MUC18) is a recently recognized cell adhesion molecule belonging to the immunoglobin gene superfamily that specifically identifies intermediate trophoblast (IT). In this study, we evaluated immunohistochemical staining of Ki-67 (using Mib-1 antibody) in Mel-CAM defined IT as an aid in the differential diagnosis of these lesions. Formalin-fixed tissue samples from 24 normal implantation sites, 19 exaggerated placental sites, five molar implantation sites, 16 placental site trophoblastic tumors, and 12 choriocarcinomas were stained with a Mel-CAM-specific polyclonal antibody and a Ki-67 antibody using streptavidin-biotin immunoperoxidase with two different chromagens. No Ki-67 nuclear labeling was seen in IT of normal implantation sites. The Ki-67 index (mean +/- standard deviation) in IT of exaggerated placental site was near zero, but in the molar implantation sites the Ki-67 index was 5.2% +/- 4.0%. In contrast, the Ki-67 index in IT of placental site trophoblastic tumor was 14% +/- 6.9% and in choriocarcinoma was 69% +...Continue Reading

References

Mar 1, 1992·Pediatric Pathology·H K Wolf, G K Michalopoulos
Jan 1, 1991·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·H ArnholdtU Löhrs
Feb 1, 1990·The Journal of Clinical Endocrinology and Metabolism·S Tabibzadeh
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J M LehmannJ P Johnson
Dec 1, 1988·Journal of Reproductive Immunology·J N BulmerP M Johnson
Jan 1, 1984·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·R J KurmanR E Scully
Feb 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J MühlhauserM Castellucci
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·C SersJ P Johnson
Jan 1, 1996·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·M D JeffersR Smith
Nov 1, 1992·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·L A KingL B Twiggs

❮ Previous
Next ❯

Citations

Feb 21, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E Kairi-VassilatouD Hasiakos
Sep 28, 2010·Diagnostic Pathology·Robin J Ou-YangDebra L Zynger
Mar 17, 2009·Future Oncology·Annie N Y CheungMichelle K Y Siu
Jul 4, 2012·Annales de pathologie·Mojgan Devouassoux-ShisheboranLucien Frappart
Nov 20, 2015·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Zuzana CiernaLudovit Danihel
Mar 24, 2016·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Sakiko KageyamaTakaaki Hosoya
Mar 26, 1999·Der Pathologe·H HerbstT Löning
May 3, 2014·Nigerian Medical Journal : Journal of the Nigeria Medical Association·Ozhan OzdemirCemal Resat Atalay
Aug 25, 2001·Gynecologic Oncology·I M Shih, R J Kurman
Dec 31, 2014·Archives of Pathology & Laboratory Medicine·Hanna G Kaspar, Christopher P Crum
Oct 23, 2015·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Stewart F Cramer, Debra S Heller
Jul 1, 2009·Expert Opinion on Medical Diagnostics·Tsui-Lien Mao, Ie-Ming Shih
May 8, 2002·Acta histochemica·Gabriele GausHans-Georg Frank
Mar 23, 2017·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Stewart F Cramer, Debra S Heller
Aug 19, 1999·The Journal of Pathology·I M Shih
Mar 22, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ana-Maria BambergerThomas Löning
Apr 11, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·A M BambergerT Löning
Oct 18, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·F KommossH Müntefering
Feb 24, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·I M Shih, R J Kurman
May 29, 2004·The American Journal of Surgical Pathology·Albert J H SuurmeijerHarald J Hoekstra
May 3, 2000·Pathology International·N TakaiI Miyakawa
Dec 13, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Robert H Young
Jun 19, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kyu-Rae KimJae Y Ro
Jul 2, 2003·Obstetrical & Gynecological Survey·T V AjithkumarA L Minimole
Apr 25, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W Glenn McCluggage
Jul 2, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·E S Guvendag GuvenA Usubutun
Aug 19, 2007·Journal of Cancer Research and Clinical Oncology·Nadereh Behtash, Mojgan Karimi Zarchi
Feb 4, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Hui-Juan ZhangAnnie Nga-Yin Cheung
Aug 25, 2009·Advances in Anatomic Pathology·Oisin Houghton, W Glenn McCluggage
Apr 13, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Eric J ChengIe-Ming Shih
Jan 1, 2010·Cancers·Yutaka UedaTadashi Kimura
Mar 14, 2013·Korean Journal of Pathology·Woo Jung SungMi Jin Kim
Sep 16, 2003·Clinical Obstetrics and Gynecology·Rex C Bentley
Sep 16, 2003·Clinical Obstetrics and Gynecology·Louis A DaintyG Larry Maxwell
Mar 5, 2019·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Jhalak DholakiaBrigitte M Ronnett
Sep 30, 2016·Iranian Journal of Radiology : a Quarterly Journal Published by the Iranian Radiological Society·Maryam NiknejadiFarnaz Akhbari
Jan 9, 2010·Fetal and Pediatric Pathology·N J Sebire, Iain Lindsay
Mar 10, 2021·Placenta·Ana Lucia Mendes da SilvaAlexandre Urban Borbely

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Laboratory Investigation; a Journal of Technical Methods and Pathology
I M Shih, R J Kurman
Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
I M ShihR J Kurman
International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
I M Shih, R J Kurman
© 2021 Meta ULC. All rights reserved