Ki-67 quantitative evaluation as a marker of cervical intraepithelial neoplasia and human papillomavirus infection

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Marko MimicaLidija Pejković

Abstract

To assess the value of Ki-67 quantitative analysis in cervical intraepithelial neoplasia (CIN) in relation to CIN grading and human papillomavirus (HPV) group typing. Cervical samples selected retrospectively from 106 cases were analyzed immunohistochemically for Ki-67-positive nuclei in 3 epithelial layers and by polymerase chain reaction for HPV typing. The proportion of high-risk HPV positivity was 0% in normal controls and 30% in CIN 1, 57% in CIN 2, and 90% in CIN 3 groups, and there was no low-risk HPV finding in CIN 2 and CIN 3 cases (P < 0.001). High-risk HPV-positive cases exhibited significantly more Ki-67-positive nuclei per 100-mum basal membrane, which were more frequent in the middle and upper third layers of the epithelium compared with low-risk HPV and HPV-negative cases (P < 0.001). The differences among the CIN groups in the total number and in the percentages of Ki-67-positive nuclei in the lower, middle, and upper third layers of the epithelium were significant (P < 0.001). With the cutoff value of more than 33% Ki-67-positive nuclei in the middle and the upper third layers of the epithelium, Ki-67 staining demonstrated 98.4% sensitivity (60/61 cases) and 97.8% specificity (44/45 cases) for the detection of ...Continue Reading

References

Aug 19, 1999·The Journal of Pathology·J M WalboomersN Muñoz
Mar 29, 2002·Journal of Clinical Pathology·F X BoschK V Shah
Apr 12, 2002·Histopathology·M K Heatley
Nov 1, 2002·The American Journal of Surgical Pathology·Rüdiger KlaesMagnus von Knebel Doeberitz
Nov 1, 2002·The American Journal of Surgical Pathology·Arnold-Jan KruseEmiel A M Janssen
Jul 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S Nicholas AgoffLaura A Koutsky

❮ Previous
Next ❯

Citations

Jun 16, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Gyorgy B HalmosEd Schuuring
Mar 22, 2014·Biomedical Reports·Jing-Xia HuLianqin Li
Oct 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Ashraf FakhrjouMohammad Naghavi-Behzad
Jan 7, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Amr AlsabbaghChristina McCord

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bowen's Disease

Bowen's disease is thought of as an easily-treatable early stage of skin cancer, characterized by red, scaly patches on the skin. Discover the latest research on Bowen's disease here.