Ki67, CD105, and α-SMA expression supports the transformation relevant dysplastic features in the atrophic epithelium of oral submucous fibrosis

PloS One
Amol Ramchandra GadbailShankargouda Patil

Abstract

The grading of oral epithelial dysplasia is not possible in the atrophic epithelium of oral submucous fibrosis (OSMF). Recently, we found that features such as increased basal cell layer hyperplasia, abnormal superficial mitosis, increased nuclear-cytoplasmic ratio, increased nuclear size, and hyperchromasia represent transformation-relevant dysplastic features in the atrophic epithelium of OSMF. The presence of these features can be considered a high-risk feature for patients. However, these findings have not been tested and authenticated using markers relevant to oral carcinogenesis. Paraffin-embedded tissues from 30 normal oral mucosa (NOM) and 50 OSMF were retrieved from 2008 to 2016 and subjected to immunohistochemical expression using Ki67, CD105 and α-SMA antibodies. Ki67 LI showed significant increases from NOM (12.47±2.34) to LRED (23.47±3.75) to HRED (34.31±7.31) (<0.0001). Similarly, MVD was increased significantly from NOM (3.53±5.17) to LRED (27.57±12.25) to HRED (46.18±12.55) (p<0.0001). The expression of α-SMA was significantly increased from LRED (0.21±0.41) to HRED (1.13±0.56) (<0.0001). The Ki67 LI and α-SMA; MVD and α-SMA; and Ki67Ki67 LI and MVD in NOM, LRED and HRED showed a statistically significant positi...Continue Reading

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Citations

Jul 22, 2019·Journal of Investigative and Clinical Dentistry·Amol R GadbailShankargouda Patil
May 12, 2020·Oral Diseases·Min-Hsuan ChiangYan-Hsiung Wang
Nov 5, 2020·International Journal of Molecular Sciences·Ru-Hsiu ChengJiiang-Huei Jeng
Mar 9, 2021·Expert Review of Molecular Diagnostics·Kenneth P H PritzkerDavid Mock

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Methods Mentioned

BETA
Alpha-SMA
biopsy

Software Mentioned

Leica Qwin standard
SPSS

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