Ki67 Changes Identify Worse Outcomes in Residual Breast Cancer Tumors After Neoadjuvant Chemotherapy

The Oncologist
Paula Cabrera-GaleanaOscar Arrieta

Abstract

Several breast cancer (BC) trials have adopted pathological complete response (pCR) as a surrogate marker of long-term treatment efficacy. In patients with luminal subtype, pCR seems less important for outcome prediction. BC is a heterogeneous disease, which is evident in residual tumors after neoadjuvant-chemotherapy (NAC). This study evaluates changes in Ki67 in relation to disease-free survival (DFS) and overall survival (OS) in patients without pCR. Four hundred thirty-five patients with stage IIA-IIIC BC without pCR after standard NAC with anthracycline and paclitaxel were analyzed. We analyzed the decrease or lack of decrease in the percentage of Ki67-positive cells between core biopsy samples and surgical specimens and correlated this value with outcome. Twenty-five percent of patients presented with luminal A-like tumors, 45% had luminal B-like tumors, 14% had triple-negative BC, 5% had HER2-positive BC, and 11% had triple-positive BC. Patients were predominantly diagnosed with stage III disease (52%) and high-grade tumors (46%). Median Ki67 level was 20% before NAC, which decreased to a median of 10% after NAC. Fifty-seven percent of patients had a decrease in Ki67 percentage. Ki67 decrease significantly correlated wit...Continue Reading

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Citations

May 8, 2018·The Oncologist·Nathalie LeVasseur, Karen A Gelmon
Oct 2, 2019·Experimental and Therapeutic Medicine·Helena SkálováIvana Tichá
Dec 15, 2019·Journal of Clinical Medicine·Eugeni Lopez-BonetJavier A Menendez
Jul 20, 2020·BMC Cancer·Laura Rey-VargasSilvia J Serrano-Gomez
Mar 6, 2019·Therapeutic Advances in Medical Oncology·Rafael CaparicaMartine Piccart
Mar 6, 2021·Critical Reviews in Oncology/hematology·Rosalba TorrisiArmando Santoro
Aug 17, 2021·The Journal of Obstetrics and Gynaecology Research·Ryusuke KayaSeiji Isonishi

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